RANBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= RANBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RANBP1
  * **<color #00a2e8>Official Name</color>**: RAN binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5902|5902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43487|P43487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RANBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RANBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7882974, PubMed:7616957). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ran BP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic centrosome separation|
|regulation of mitotic centrosome separation|
|GDP-dissociation inhibitor activity|
|positive regulation of centrosome cycle|
|Ran GTPase binding|
|positive regulation of mitotic nuclear division|
|regulation of centrosome cycle|
|positive regulation of nuclear division|
|nuclear pore|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|nuclear envelope|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|GTPase activator activity|
|positive regulation of cell cycle process|
|cadherin binding|
|positive regulation of cell cycle|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|centrosome|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|viral process|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|intracellular transport|
|positive regulation of molecular function|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-3.54|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.83|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.69|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.49|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.48|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.41|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.33|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.31|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.31|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.29|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.26|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.23|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.22|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.21|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.21|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.2|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.19|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.18|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.18|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.12|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.11|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.11|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.1|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.08|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.05|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.04|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.99|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.99|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.96|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.86|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.84|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.81|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.8|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.76|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.73|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.73|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.73|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.72|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.71|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup188|NUP188]]|0.476|
|[[:human genes:o:otub1|OTUB1]]|0.47|
|[[:human genes:r:rqcd1|RQCD1]]|0.449|
|[[:human genes:n:nup35|NUP35]]|0.438|
|[[:human genes:t:tnpo1|TNPO1]]|0.437|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.431|
|[[:human genes:u:usp9x|USP9X]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RANBP1 Expression in NALM6 Cells: 8.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>