RANBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= RANBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RANBP2
  * **<color #00a2e8>Official Name</color>**: RAN binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5903|5903]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49792|P49792]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RANBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RANBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601181|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). {ECO:0000269|PubMed:11792325, ECO:0000269|PubMed:12032081, ECO:0000269|PubMed:15378033, ECO:0000269|PubMed:15931224, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:22194619}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ran BP1|
|IR1-M|
|zf-RanBP|
|TPR 1|
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic periphery of the nuclear pore complex|
|nuclear pore cytoplasmic filaments|
|annulate lamellae|
|positive regulation of glucokinase activity|
|positive regulation of hexokinase activity|
|regulation of glucokinase activity|
|regulation of hexokinase activity|
|nuclear pore nuclear basket|
|nuclear inclusion body|
|SUMO transferase activity|
|NLS-bearing protein import into nucleus|
|cyclosporin A binding|
|centrosome localization|
|microtubule organizing center localization|
|response to amphetamine|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|Ran GTPase binding|
|tRNA transport|
|ncRNA export from nucleus|
|regulation of gluconeogenesis|
|peptidyl-prolyl cis-trans isomerase activity|
|response to amine|
|protein peptidyl-prolyl isomerization|
|response to bronchodilator|
|intracellular transport of virus|
|host cell|
|transport of virus|
|positive regulation of cellular carbohydrate metabolic process|
|peptidyl-proline modification|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of cellular response to heat|
|positive regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of carbohydrate biosynthetic process|
|protein import into nucleus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|regulation of glucose metabolic process|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|regulation of cellular carbohydrate metabolic process|
|protein import|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|protein folding|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|protein-containing complex binding|
|GTPase activator activity|
|response to xenobiotic stimulus|
|peptidyl-lysine modification|
|positive regulation of GTPase activity|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|regulation of GTPase activity|
|response to toxic substance|
|positive regulation of kinase activity|
|organelle localization|
|positive regulation of transferase activity|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|response to drug|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|mitochondrion|
|regulation of hydrolase activity|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.89|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.87|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.8|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.7|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.7|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.75|
|[[:results:exp73|LJH685 5μM R02 exp73]]|1.91|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.02|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.12|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.525|
|[[:human genes:p:psmb4|PSMB4]]|0.518|
|[[:human genes:c:chd4|CHD4]]|0.503|
|[[:human genes:d:dtl|DTL]]|0.501|
|[[:human genes:m:myo1h|MYO1H]]|0.499|
|[[:human genes:c:cbwd3|CBWD3]]|0.497|
|[[:human genes:z:zfand5|ZFAND5]]|0.495|
|[[:human genes:r:rpl35|RPL35]]|0.494|
|[[:human genes:a:aamp|AAMP]]|0.493|
|[[:human genes:s:smg1|SMG1]]|0.489|
|[[:human genes:p:psmd11|PSMD11]]|0.487|
|[[:human genes:c:copa|COPA]]|0.486|
|[[:human genes:u:utp3|UTP3]]|0.485|
|[[:human genes:c:cbwd5|CBWD5]]|0.484|
|[[:human genes:p:pcf11|PCF11]]|0.479|
|[[:human genes:p:psmc2|PSMC2]]|0.479|
|[[:human genes:s:snip1|SNIP1]]|0.478|
|[[:human genes:o:or10g3|OR10G3]]|0.472|
|[[:human genes:c:copg1|COPG1]]|0.471|
|[[:human genes:r:rps2|RPS2]]|0.471|
|[[:human genes:z:znf830|ZNF830]]|0.471|
|[[:human genes:c:cbwd6|CBWD6]]|0.47|
|[[:human genes:c:copz1|COPZ1]]|0.468|
|[[:human genes:p:prss8|PRSS8]]|0.468|
|[[:human genes:n:npipb5|NPIPB5]]|0.467|
|[[:human genes:r:rpl30|RPL30]]|0.466|
|[[:human genes:a:akirin2|AKIRIN2]]|0.465|
|[[:human genes:n:nsf|NSF]]|0.462|
|[[:human genes:d:disp2|DISP2]]|0.462|
|[[:human genes:n:narfl|NARFL]]|0.462|
|[[:human genes:p:pan3|PAN3]]|0.461|
|[[:human genes:p:psma6|PSMA6]]|0.461|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.459|
|[[:human genes:c:cep192|CEP192]]|0.457|
|[[:human genes:m:med14|MED14]]|0.457|
|[[:human genes:m:med17|MED17]]|0.456|
|[[:human genes:t:twistnb|TWISTNB]]|0.455|
|[[:human genes:a:atp1a3|ATP1A3]]|0.455|
|[[:human genes:t:tceb3c|TCEB3C]]|0.453|
|[[:human genes:r:rbbp5|RBBP5]]|0.45|
|[[:human genes:p:psmb2|PSMB2]]|0.45|
|[[:human genes:s:slc4a1|SLC4A1]]|0.449|
|[[:human genes:i:ik|IK]]|0.449|
|[[:human genes:p:prim1|PRIM1]]|0.449|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.448|
|[[:human genes:c:cactin|CACTIN]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.448|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.447|
|[[:human genes:a:ankle1|ANKLE1]]|0.443|
|[[:human genes:n:nop16|NOP16]]|0.443|
|[[:human genes:t:tpx2|TPX2]]|0.443|
|[[:human genes:n:napa|NAPA]]|0.442|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.441|
|[[:human genes:a:aqr|AQR]]|0.441|
|[[:human genes:t:tsg101|TSG101]]|0.44|
|[[:human genes:l:lad1|LAD1]]|0.439|
|[[:human genes:s:supt6h|SUPT6H]]|0.438|
|[[:human genes:r:rad51|RAD51]]|0.437|
|[[:human genes:c:cdca5|CDCA5]]|0.437|
|[[:human genes:r:rnpc3|RNPC3]]|0.436|
|[[:human genes:p:psmd1|PSMD1]]|0.435|
|[[:human genes:o:orc1|ORC1]]|0.434|
|[[:human genes:g:gbf1|GBF1]]|0.434|
|[[:human genes:h:hivep3|HIVEP3]]|0.434|
|[[:human genes:v:vps54|VPS54]]|0.433|
|[[:human genes:d:dock6|DOCK6]]|0.433|
|[[:human genes:k:krt78|KRT78]]|0.432|
|[[:human genes:o:orc6|ORC6]]|0.432|
|[[:human genes:c:ccna2|CCNA2]]|0.432|
|[[:human genes:e:exosc6|EXOSC6]]|0.432|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.431|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.431|
|[[:human genes:r:rbm39|RBM39]]|0.431|
|[[:human genes:c:cdc45|CDC45]]|0.431|
|[[:human genes:t:taf1|TAF1]]|0.43|
|[[:human genes:p:psmc1|PSMC1]]|0.43|
|[[:human genes:e:exosc9|EXOSC9]]|0.429|
|[[:human genes:p:polr2j3|POLR2J3]]|0.428|
|[[:human genes:n:nbpf10|NBPF10]]|0.427|
|[[:human genes:u:ubap1|UBAP1]]|0.427|
|[[:human genes:n:nup43|NUP43]]|0.426|
|[[:human genes:k:kctd17|KCTD17]]|0.425|
|[[:human genes:k:kif3c|KIF3C]]|0.425|
|[[:human genes:x:xab2|XAB2]]|0.425|
|[[:human genes:r:rrp7a|RRP7A]]|0.424|
|[[:human genes:c:chmp4b|CHMP4B]]|0.424|
|[[:human genes:r:rps12|RPS12]]|0.423|
|[[:human genes:n:nol12|NOL12]]|0.423|
|[[:human genes:a:ankle2|ANKLE2]]|0.423|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.423|
|[[:human genes:r:rps3|RPS3]]|0.422|
|[[:human genes:a:aatf|AATF]]|0.422|
|[[:human genes:n:nupl1|NUPL1]]|0.422|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.421|
|[[:human genes:n:nup85|NUP85]]|0.421|
|[[:human genes:c:chchd3|CHCHD3]]|0.421|
|[[:human genes:p:psmd7|PSMD7]]|0.42|
|[[:human genes:t:terf2|TERF2]]|0.419|
|[[:human genes:s:supt5h|SUPT5H]]|0.418|
|[[:human genes:g:gosr2|GOSR2]]|0.418|
|[[:human genes:r:rps28|RPS28]]|0.417|
|[[:human genes:t:tspy8|TSPY8]]|0.417|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.417|
|[[:human genes:n:nup153|NUP153]]|0.416|
|[[:human genes:s:smg7|SMG7]]|0.416|
|[[:human genes:z:znf541|ZNF541]]|0.416|
|[[:human genes:f:fbxo5|FBXO5]]|0.415|
|[[:human genes:n:nbpf16|NBPF16]]|0.415|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.415|
|[[:human genes:p:psmc3|PSMC3]]|0.415|
|[[:human genes:s:sap30bp|SAP30BP]]|0.415|
|[[:human genes:g:gga3|GGA3]]|0.415|
|[[:human genes:v:vasn|VASN]]|0.414|
|[[:human genes:m:mbtd1|MBTD1]]|0.413|
|[[:human genes:r:rrp15|RRP15]]|0.412|
|[[:human genes:f:fbxw9|FBXW9]]|0.411|
|[[:human genes:z:znf106|ZNF106]]|0.411|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.411|
|[[:human genes:a:ahctf1|AHCTF1]]|0.41|
|[[:human genes:g:golga8j|GOLGA8J]]|0.409|
|[[:human genes:v:vps28|VPS28]]|0.408|
|[[:human genes:p:pan2|PAN2]]|0.408|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.407|
|[[:human genes:t:timeless|TIMELESS]]|0.407|
|[[:human genes:p:polr2f|POLR2F]]|0.407|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.407|
|[[:human genes:c:cwc22|CWC22]]|0.406|
|[[:human genes:c:ccdc94|CCDC94]]|0.406|
|[[:human genes:p:psmd3|PSMD3]]|0.406|
|[[:human genes:s:sec13|SEC13]]|0.406|
|[[:human genes:p:psmc5|PSMC5]]|0.406|
|[[:human genes:o:ogfr|OGFR]]|0.405|
|[[:human genes:r:rangap1|RANGAP1]]|0.405|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.405|
|[[:human genes:p:pole|POLE]]|0.404|
|[[:human genes:d:dhx38|DHX38]]|0.404|
|[[:human genes:m:mdm2|MDM2]]|0.404|
|[[:human genes:r:rpl34|RPL34]]|0.404|
|[[:human genes:z:znf655|ZNF655]]|0.403|
|[[:human genes:c:cdca3|CDCA3]]|0.403|
|[[:human genes:d:dgcr14|DGCR14]]|0.403|
|[[:human genes:p:pigs|PIGS]]|0.403|
|[[:human genes:c:col2a1|COL2A1]]|0.403|
|[[:human genes:h:hap1|HAP1]]|0.402|
|[[:human genes:m:map7d1|MAP7D1]]|0.402|
|[[:human genes:p:pola2|POLA2]]|0.402|
|[[:human genes:l:lipe|LIPE]]|0.401|
|[[:human genes:t:tinf2|TINF2]]|0.401|
|[[:human genes:r:rps7|RPS7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 897
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RANBP2 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>