RANGRF [The Human Chemical-Genetic Interaction Map Project]

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======= RANGRF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RANGRF
  * **<color #00a2e8>Official Name</color>**: RAN guanine nucleotide release factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29098|29098]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HD47|Q9HD47]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RANGRF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RANGRF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607954|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). {ECO:0000269|PubMed:11290418, ECO:0000269|PubMed:18184654, ECO:0000269|PubMed:21621375, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:29040603}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mog1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of microtubule nucleation by Ran protein signal transduction|
|regulation of bundle of His cell action potential|
|Ran protein signal transduction|
|Ran guanyl-nucleotide exchange factor activity|
|regulation of membrane depolarization during cardiac muscle cell action potential|
|regulation of microtubule nucleation|
|regulation of membrane depolarization during action potential|
|regulation of cardiac muscle cell action potential involved in regulation of contraction|
|positive regulation of protein localization to cell surface|
|protein exit from endoplasmic reticulum|
|regulation of cardiac muscle cell action potential|
|sodium channel regulator activity|
|Ran GTPase binding|
|regulation of cardiac muscle cell contraction|
|regulation of protein localization to cell surface|
|regulation of actin filament-based movement|
|regulation of membrane depolarization|
|intercalated disc|
|regulation of action potential|
|regulation of microtubule polymerization|
|regulation of sodium ion transmembrane transporter activity|
|positive regulation of protein localization to plasma membrane|
|rough endoplasmic reticulum|
|positive regulation of protein localization to cell periphery|
|regulation of sodium ion transmembrane transport|
|regulation of cardiac conduction|
|caveola|
|regulation of cardiac muscle contraction|
|regulation of microtubule polymerization or depolymerization|
|regulation of sodium ion transport|
|regulation of striated muscle contraction|
|regulation of protein localization to plasma membrane|
|regulation of heart rate|
|guanyl-nucleotide exchange factor activity|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|ion channel binding|
|regulation of muscle contraction|
|regulation of protein localization to membrane|
|regulation of microtubule cytoskeleton organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|regulation of muscle system process|
|regulation of heart contraction|
|Ras protein signal transduction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of blood circulation|
|small GTPase mediated signal transduction|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|regulation of supramolecular fiber organization|
|Golgi vesicle transport|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of membrane potential|
|regulation of protein complex assembly|
|regulation of ion transmembrane transport|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|regulation of transmembrane transport|
|regulation of system process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|ion homeostasis|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of cellular component movement|
|intracellular protein transport|
|regulation of protein localization|
|chemical homeostasis|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RANGRF Expression in NALM6 Cells: 4.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>