RAP1GDS1 [The Human Chemical-Genetic Interaction Map Project]

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======= RAP1GDS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAP1GDS1
  * **<color #00a2e8>Official Name</color>**: Rap1 GTPase-GDP dissociation stimulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5910|5910]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52306|P52306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAP1GDS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAP1GDS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179502|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arm|
|V-ATPase H N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endoplasmic reticulum calcium ion concentration|
|positive regulation of mitochondrial calcium ion concentration|
|myosin filament assembly|
|myosin filament organization|
|vascular smooth muscle contraction|
|endoplasmic reticulum calcium ion homeostasis|
|mitochondrial calcium ion homeostasis|
|vasoconstriction|
|negative regulation of blood vessel diameter|
|smooth muscle contraction|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|vascular process in circulatory system|
|muscle contraction|
|GTPase activator activity|
|muscle system process|
|blood circulation|
|circulatory system process|
|positive regulation of GTPase activity|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|cellular metal ion homeostasis|
|actin filament-based process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|endoplasmic reticulum|
|cytoskeleton organization|
|chemical homeostasis|
|mitochondrion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|homeostatic process|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.17|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.73|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.496|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAP1GDS1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>