RAPGEF4 [The Human Chemical-Genetic Interaction Map Project]

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======= RAPGEF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RAPGEF4
  * **<color #00a2e8>Official Name</color>**: Rap guanine nucleotide exchange factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11069|11069]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WZA2|Q8WZA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RAPGEF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RAPGEF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606058|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity). {ECO:0000250, ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:9856955}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEP|
|RasGEF|
|cNMP binding|
|RasGEF N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ras GTPase binding|
|Ras guanyl-nucleotide exchange factor activity|
|cAMP binding|
|hippocampal mossy fiber to CA3 synapse|
|insulin secretion|
|calcium-ion regulated exocytosis|
|peptide hormone secretion|
|hormone secretion|
|hormone transport|
|guanyl-nucleotide exchange factor activity|
|regulation of synaptic vesicle cycle|
|cAMP-mediated signaling|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|signal release|
|cyclic-nucleotide-mediated signaling|
|peptide secretion|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|regulation of exocytosis|
|regulation of hormone secretion|
|small GTPase mediated signal transduction|
|second-messenger-mediated signaling|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|G protein-coupled receptor signaling pathway|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.72|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.81|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.91|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.94|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RAPGEF4 Expression in NALM6 Cells: 0.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>