RBBP6 [The Human Chemical-Genetic Interaction Map Project]

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======= RBBP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBBP6
  * **<color #00a2e8>Official Name</color>**: RB binding protein 6, ubiquitin ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5930|5930]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6E9|Q7Z6E9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBBP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBBP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600938|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|U-box|
|DWNN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multicellular organism growth|
|somite development|
|regulation of DNA replication|
|chromosome|
|DNA replication|
|ubiquitin protein ligase activity|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|in utero embryonic development|
|developmental growth|
|growth|
|nuclear speck|
|embryonic organ development|
|protein kinase binding|
|mRNA processing|
|centrosome|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|protein ubiquitination|
|mRNA metabolic process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|embryo development|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|epithelium development|
|proteolysis|
|RNA binding|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.97|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.91|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:riok1|RIOK1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 399/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|20/28|
|bone|17/26|
|breast|19/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|11/21|
|liver|14/20|
|lung|40/75|
|lymphocyte|12/16|
|ovary|11/26|
|pancreas|10/24|
|peripheral nervous system|13/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|15/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|14/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1019
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBBP6 Expression in NALM6 Cells: 7.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>