RBM14 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM14
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10432|10432]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PK6|Q96PK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612409|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a ribonucleoprotein that functions as a general nuclear coactivator, and an RNA splicing modulator. This protein contains two RNA recognition motifs (RRM) at the N-terminus, and multiple hexapeptide repeat domain at the C-terminus that interacts with thyroid hormone receptor-binding protein (TRBP), and is required for transcription activation. Alternatively spliced transcript variants encoding different isoforms (with opposing effects on transcription) have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucocorticoid receptor signaling pathway|
|negative regulation of centriole replication|
|corticosteroid receptor signaling pathway|
|negative regulation of centrosome duplication|
|negative regulation of centrosome cycle|
|intracellular estrogen receptor signaling pathway|
|regulation of centriole replication|
|centriole assembly|
|mediator complex|
|negative regulation of organelle assembly|
|regulation of centrosome duplication|
|histone deacetylation|
|protein deacetylation|
|SMAD protein signal transduction|
|regulation of centrosome cycle|
|protein deacylation|
|macromolecule deacylation|
|nuclear receptor transcription coactivator activity|
|intracellular steroid hormone receptor signaling pathway|
|protein binding, bridging|
|transcription coregulator activity|
|microtubule organizing center organization|
|steroid hormone mediated signaling pathway|
|negative regulation of cytoskeleton organization|
|ribonucleoprotein complex|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|regulation of microtubule cytoskeleton organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription factor complex|
|DNA replication|
|regulation of organelle assembly|
|DNA recombination|
|regulation of microtubule-based process|
|activation of innate immune response|
|negative regulation of cell cycle process|
|response to steroid hormone|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|nuclear speck|
|regulation of innate immune response|
|positive regulation of defense response|
|microtubule cytoskeleton organization|
|DNA repair|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|negative regulation of cell cycle|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|activation of immune response|
|microtubule-based process|
|chromatin organization|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|response to lipid|
|nucleolus|
|positive regulation of immune response|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|regulation of cellular component biogenesis|
|chromosome organization|
|regulation of response to external stimulus|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.83|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.65|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.37|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.35|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.34|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-2.31|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.25|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.21|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.13|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.13|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.08|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.05|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.99|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.95|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.93|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.9|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.9|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.9|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.89|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.86|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.85|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.85|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.81|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.8|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.74|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.74|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.73|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.71|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.7|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.9|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.02|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.31|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.32|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.33|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.42|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.44|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.92|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.84|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|3.87|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|4.56|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|4.98|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|5.42|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|5.54|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|6.07|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|6.36|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|6.54|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|6.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad2l1|MAD2L1]]|0.816|
|[[:human genes:m:mad1l1|MAD1L1]]|0.802|
|[[:human genes:b:bub3|BUB3]]|0.763|
|[[:human genes:k:kntc1|KNTC1]]|0.746|
|[[:human genes:b:bub1b|BUB1B]]|0.72|
|[[:human genes:z:zw10|ZW10]]|0.72|
|[[:human genes:t:trip13|TRIP13]]|0.684|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.655|
|[[:human genes:z:zwilch|ZWILCH]]|0.648|
|[[:human genes:f:fnta|FNTA]]|0.574|
|[[:human genes:p:pelo|PELO]]|0.532|
|[[:human genes:m:mars|MARS]]|0.506|
|[[:human genes:m:med16|MED16]]|0.499|
|[[:human genes:d:ddx20|DDX20]]|0.496|
|[[:human genes:r:rtcb|RTCB]]|0.494|
|[[:human genes:d:dpagt1|DPAGT1]]|0.493|
|[[:human genes:t:tbca|TBCA]]|0.492|
|[[:human genes:g:gnb1l|GNB1L]]|0.49|
|[[:human genes:c:cdc20|CDC20]]|0.479|
|[[:human genes:f:fntb|FNTB]]|0.471|
|[[:human genes:a:alg1|ALG1]]|0.465|
|[[:human genes:p:pam16|PAM16]]|0.464|
|[[:human genes:t:trmt5|TRMT5]]|0.463|
|[[:human genes:s:srp72|SRP72]]|0.459|
|[[:human genes:u:uap1|UAP1]]|0.456|
|[[:human genes:r:rnmt|RNMT]]|0.456|
|[[:human genes:e:eprs|EPRS]]|0.448|
|[[:human genes:n:nsmce1|NSMCE1]]|0.448|
|[[:human genes:t:tti2|TTI2]]|0.446|
|[[:human genes:d:dbr1|DBR1]]|0.446|
|[[:human genes:d:dctn6|DCTN6]]|0.446|
|[[:human genes:p:polr3b|POLR3B]]|0.444|
|[[:human genes:p:polr3h|POLR3H]]|0.443|
|[[:human genes:p:pmm2|PMM2]]|0.44|
|[[:human genes:t:thg1l|THG1L]]|0.44|
|[[:human genes:p:ppp4c|PPP4C]]|0.433|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.433|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.427|
|[[:human genes:a:aars|AARS]]|0.426|
|[[:human genes:d:dhps|DHPS]]|0.425|
|[[:human genes:g:gfpt1|GFPT1]]|0.423|
|[[:human genes:o:osgep|OSGEP]]|0.418|
|[[:human genes:a:alg14|ALG14]]|0.418|
|[[:human genes:r:rad1|RAD1]]|0.418|
|[[:human genes:s:spcs2|SPCS2]]|0.418|
|[[:human genes:t:tti1|TTI1]]|0.417|
|[[:human genes:g:gemin5|GEMIN5]]|0.416|
|[[:human genes:c:cdipt|CDIPT]]|0.415|
|[[:human genes:r:rabggtb|RABGGTB]]|0.412|
|[[:human genes:h:hbs1l|HBS1L]]|0.412|
|[[:human genes:v:vmp1|VMP1]]|0.41|
|[[:human genes:h:hars|HARS]]|0.408|
|[[:human genes:t:tsen54|TSEN54]]|0.407|
|[[:human genes:e:eif4e|EIF4E]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 607/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|26/28|
|bone|22/25|
|breast|27/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|13/15|
|kidney|20/21|
|liver|15/20|
|lung|59/75|
|lymphocyte|12/14|
|ovary|21/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|19/22|
|urinary tract|25/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM14 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>