RBM17 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM17
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84991|84991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96I25|Q96I25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606935|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. {ECO:0000269|PubMed:12015979, ECO:0000269|PubMed:17589525}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-patch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alternative mRNA splicing, via spliceosome|
|regulation of alternative mRNA splicing, via spliceosome|
|spliceosomal complex|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|DNA repair|
|mRNA metabolic process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|cellular response to stress|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.1|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cul4a|CUL4A]]|0.443|
|[[:human genes:t:thoc6|THOC6]]|0.407|
|[[:human genes:h:hars|HARS]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 565/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|19/28|
|bone|20/26|
|breast|19/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|17/21|
|liver|14/20|
|lung|61/75|
|lymphocyte|14/16|
|ovary|21/26|
|pancreas|19/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|20/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 154
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM17 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>