RBM19 [The Human Chemical-Genetic Interaction Map Project]

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======= RBM19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM19
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9904|9904]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4C8|Q9Y4C8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616444|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in embryo pre-implantation development. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA cis splicing, via spliceosome|
|positive regulation of embryonic development|
|regulation of alternative mRNA splicing, via spliceosome|
|regulation of mRNA splicing, via spliceosome|
|chromosome|
|regulation of embryonic development|
|regulation of RNA splicing|
|regulation of mRNA processing|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|positive regulation of developmental process|
|RNA binding|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.3|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.72|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 462/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|12/28|
|bone|19/26|
|breast|23/33|
|central nervous system|40/56|
|cervix|1/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|10/21|
|liver|12/20|
|lung|49/75|
|lymphocyte|8/16|
|ovary|15/26|
|pancreas|15/24|
|peripheral nervous system|8/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|16/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM19 Expression in NALM6 Cells: 5.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>