RBM38 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RBM38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBM38
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein 38
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55544|55544]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0Z9|Q9H0Z9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBM38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBM38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269|PubMed:17050675, ECO:0000269|PubMed:19285943}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|3-UTR-mediated mRNA stabilization|
|mRNA stabilization|
|RNA stabilization|
|negative regulation of mRNA catabolic process|
|regulation of myotube differentiation|
|negative regulation of RNA catabolic process|
|mRNA 3-UTR binding|
|negative regulation of mRNA metabolic process|
|regulation of striated muscle cell differentiation|
|regulation of RNA splicing|
|regulation of muscle cell differentiation|
|ribonucleoprotein complex|
|mRNA binding|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|RNA splicing|
|mRNA processing|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|regulation of cellular catabolic process|
|RNA processing|
|regulation of catabolic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.58|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.04|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.03|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.99|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.94|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.93|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.82|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.76|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.71|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.74|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.74|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.74|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.8|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.86|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.86|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.88|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.9|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.93|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.03|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.03|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.27|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.3|
|[[:results:exp453|B02 10μM R08 exp453]]|2.36|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.75|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.31|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prr14l|PRR14L]]|0.559|
|[[:human genes:z:zbtb18|ZBTB18]]|0.493|
|[[:human genes:k:kdm6a|KDM6A]]|0.449|
|[[:human genes:a:anp32a|ANP32A]]|0.448|
|[[:human genes:p:pds5b|PDS5B]]|0.405|
|[[:human genes:f:fam122a|FAM122A]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBM38 Expression in NALM6 Cells: 6.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>