RBMX2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RBMX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RBMX2
  * **<color #00a2e8>Official Name</color>**: RNA binding motif protein X-linked 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51634|51634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y388|Q9Y388]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RBMX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RBMX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|first spliceosomal transesterification activity|
|U2 snRNP|
|U2-type precatalytic spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.59|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-2.38|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.33|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.3|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.29|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.12|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.12|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.04|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-2.03|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.96|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.91|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.91|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.85|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.81|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.79|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.78|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.77|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.76|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.73|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.7|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.73|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.74|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.78|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.82|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.88|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.01|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.12|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.526|
|[[:human genes:r:rpe|RPE]]|0.487|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.471|
|[[:human genes:l:lsm10|LSM10]]|0.459|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.457|
|[[:human genes:u:uhrf1|UHRF1]]|0.456|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.454|
|[[:human genes:t:triap1|TRIAP1]]|0.454|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.452|
|[[:human genes:p:pik3r4|PIK3R4]]|0.448|
|[[:human genes:h:hccs|HCCS]]|0.445|
|[[:human genes:c:cct7|CCT7]]|0.445|
|[[:human genes:v:vrk1|VRK1]]|0.444|
|[[:human genes:c:chchd4|CHCHD4]]|0.444|
|[[:human genes:t:telo2|TELO2]]|0.44|
|[[:human genes:t:trip12|TRIP12]]|0.434|
|[[:human genes:e:eif3f|EIF3F]]|0.434|
|[[:human genes:v:vezt|VEZT]]|0.43|
|[[:human genes:b:bcs1l|BCS1L]]|0.429|
|[[:human genes:t:thg1l|THG1L]]|0.427|
|[[:human genes:m:mrps11|MRPS11]]|0.425|
|[[:human genes:s:srp14|SRP14]]|0.423|
|[[:human genes:e:eno1|ENO1]]|0.418|
|[[:human genes:r:rptor|RPTOR]]|0.416|
|[[:human genes:a:adsl|ADSL]]|0.416|
|[[:human genes:a:alg1|ALG1]]|0.415|
|[[:human genes:h:haus8|HAUS8]]|0.41|
|[[:human genes:d:dohh|DOHH]]|0.41|
|[[:human genes:a:atxn10|ATXN10]]|0.409|
|[[:human genes:g:gmppb|GMPPB]]|0.408|
|[[:human genes:a:apaf1|APAF1]]|0.408|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 138/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|2/26|
|bone|2/26|
|breast|10/30|
|central nervous system|7/49|
|cervix|2/4|
|colorectal|5/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|2/14|
|kidney|6/18|
|liver|1/19|
|lung|11/72|
|lymphocyte|2/16|
|ovary|5/25|
|pancreas|2/22|
|peripheral nervous system|5/15|
|plasma cell|5/12|
|prostate|0/1|
|skin|5/20|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10771
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RBMX2 Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>