RCSD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RCSD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RCSD1
  * **<color #00a2e8>Official Name</color>**: RCSD domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92241|92241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6JBY9|Q6JBY9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RCSD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RCSD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly. {ECO:0000269|PubMed:15850461}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RCSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular hyperosmotic response|
|hyperosmotic response|
|skeletal muscle contraction|
|cellular response to osmotic stress|
|multicellular organismal movement|
|musculoskeletal movement|
|response to osmotic stress|
|actin filament|
|striated muscle contraction|
|actin filament binding|
|muscle contraction|
|muscle system process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to abiotic stimulus|
|cellular response to stress|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.08|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.74|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.7|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.85|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.88|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.1|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RCSD1 Expression in NALM6 Cells: 8.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>