RDH10 [The Human Chemical-Genetic Interaction Map Project]

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======= RDH10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RDH10
  * **<color #00a2e8>Official Name</color>**: retinol dehydrogenase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=157506|157506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZV5|Q8IZV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RDH10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RDH10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607599|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. {ECO:0000269|PubMed:12407145}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KR|
|adh short|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary lung bud formation|
|positive regulation of retinoic acid biosynthetic process|
|positive regulation of isoprenoid metabolic process|
|regulation of retinoic acid biosynthetic process|
|regulation of isoprenoid metabolic process|
|positive regulation of vitamin metabolic process|
|morphogenesis of an epithelial bud|
|bud elongation involved in lung branching|
|retinoic acid biosynthetic process|
|diterpenoid biosynthetic process|
|embryonic viscerocranium morphogenesis|
|NADP-retinol dehydrogenase activity|
|regulation of vitamin metabolic process|
|retinal metabolic process|
|nose development|
|positive regulation of hormone metabolic process|
|terpenoid biosynthetic process|
|branch elongation of an epithelium|
|morphogenesis of an epithelial fold|
|retinol dehydrogenase activity|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|isoprenoid biosynthetic process|
|retinoic acid metabolic process|
|embryonic forelimb morphogenesis|
|animal organ formation|
|embryonic camera-type eye development|
|regulation of hormone metabolic process|
|retinol metabolic process|
|forelimb morphogenesis|
|lung morphogenesis|
|embryonic cranial skeleton morphogenesis|
|cellular aldehyde metabolic process|
|cranial skeletal system development|
|primary alcohol metabolic process|
|neural crest cell development|
|positive regulation of lipid biosynthetic process|
|lipid droplet|
|stem cell development|
|mesenchymal cell development|
|metanephros development|
|neural crest cell differentiation|
|embryonic skeletal system morphogenesis|
|retinoid metabolic process|
|diterpenoid metabolic process|
|developmental growth involved in morphogenesis|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|branching morphogenesis of an epithelial tube|
|isoprenoid metabolic process|
|positive regulation of small molecule metabolic process|
|positive regulation of lipid metabolic process|
|morphogenesis of embryonic epithelium|
|appendage morphogenesis|
|limb morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|regulation of cellular ketone metabolic process|
|respiratory tube development|
|appendage development|
|limb development|
|monocarboxylic acid biosynthetic process|
|regulation of lipid biosynthetic process|
|respiratory system development|
|hormone metabolic process|
|gonad development|
|development of primary sexual characteristics|
|ear development|
|mesenchyme development|
|visual perception|
|sensory perception of light stimulus|
|skeletal system morphogenesis|
|sex differentiation|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|epithelial tube morphogenesis|
|camera-type eye development|
|alcohol metabolic process|
|urogenital system development|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|developmental growth|
|growth|
|regulation of lipid metabolic process|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|organic hydroxy compound metabolic process|
|skeletal system development|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|tube development|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|sensory perception|
|embryo development|
|oxoacid metabolic process|
|organic acid metabolic process|
|epithelium development|
|lipid metabolic process|
|nervous system process|
|reproductive process|
|reproduction|
|cell development|
|small molecule metabolic process|
|tissue development|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RDH10 Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>