RECK [The Human Chemical-Genetic Interaction Map Project]

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======= RECK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RECK
  * **<color #00a2e8>Official Name</color>**: reversion inducing cysteine rich protein with kazal motifs
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8434|8434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95980|O95980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RECK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RECK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605227|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|coreceptor activity involved in canonical Wnt signaling pathway|
|negative regulation of metalloendopeptidase activity|
|regulation of establishment of blood-brain barrier|
|negative regulation of metallopeptidase activity|
|regulation of metalloendopeptidase activity|
|blood vessel maturation|
|Wnt signalosome|
|regulation of metallopeptidase activity|
|metalloendopeptidase inhibitor activity|
|embryonic forelimb morphogenesis|
|endopeptidase inhibitor activity|
|Wnt-protein binding|
|embryo implantation|
|forelimb morphogenesis|
|sprouting angiogenesis|
|canonical Wnt signaling pathway|
|serine-type endopeptidase inhibitor activity|
|anchored component of membrane|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|anatomical structure maturation|
|positive regulation of canonical Wnt signaling pathway|
|limb morphogenesis|
|appendage morphogenesis|
|positive regulation of Wnt signaling pathway|
|appendage development|
|female pregnancy|
|limb development|
|multi-multicellular organism process|
|developmental maturation|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of canonical Wnt signaling pathway|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|extracellular matrix organization|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|extracellular structure organization|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|embryonic morphogenesis|
|tube morphogenesis|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cell development|
|embryo development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|reproductive process|
|reproduction|
|positive regulation of signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.77|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7980
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RECK Expression in NALM6 Cells: 3.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>