REEP6 [The Human Chemical-Genetic Interaction Map Project]

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======= REEP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REEP6
  * **<color #00a2e8>Official Name</color>**: receptor accessory protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=92840|92840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96HR9|Q96HR9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REEP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REEP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609346|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene may be involved in the transport of receptors from the endoplasmic reticulum (ER) to the cell surface. The encoded protein may also play a role in regulating ER membrane structure. This gene is required for the proper development of retinal rods and photoreceptors, with defects in this gene being associated with retinitis pigmentosa 77. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in intracellular protein transport from the endoplasmic reticulum to the cell surface (By similarity). Required for correct function and survival of retinal photoreceptors (PubMed:27889058). {ECO:0000250|UniProtKB:Q9JM62, ECO:0000269|PubMed:27889058}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TB2 DP1 HVA22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rod spherule|
|detection of light stimulus involved in sensory perception|
|detection of light stimulus involved in visual perception|
|detection of visible light|
|photoreceptor inner segment|
|clathrin-coated vesicle membrane|
|detection of light stimulus|
|apical part of cell|
|detection of external stimulus|
|detection of abiotic stimulus|
|visual perception|
|sensory perception of light stimulus|
|response to light stimulus|
|regulation of intracellular transport|
|response to radiation|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|sensory perception|
|endoplasmic reticulum|
|response to abiotic stimulus|
|nervous system process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9194
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REEP6 Expression in NALM6 Cells: -0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>