REG3A [The Human Chemical-Genetic Interaction Map Project]

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======= REG3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: REG3A
  * **<color #00a2e8>Official Name</color>**: regenerating family member 3 alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5068|5068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06141|Q06141]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=REG3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20REG3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167805|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. {ECO:0000269|PubMed:16931762}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell wall disruption in other organism|
|negative regulation of keratinocyte differentiation|
|oligosaccharide binding|
|positive regulation of keratinocyte proliferation|
|negative regulation of epidermal cell differentiation|
|peptidoglycan binding|
|negative regulation of epidermis development|
|regulation of keratinocyte proliferation|
|acute-phase response|
|negative regulation of epithelial cell differentiation|
|regulation of keratinocyte differentiation|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|positive regulation of wound healing|
|regulation of epidermal cell differentiation|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|positive regulation of response to wounding|
|acute inflammatory response|
|regulation of epidermis development|
|antimicrobial humoral response|
|transmembrane signaling receptor activity|
|regulation of wound healing|
|regulation of epithelial cell differentiation|
|modification of morphology or physiology of other organism|
|regulation of response to wounding|
|carbohydrate binding|
|positive regulation of epithelial cell proliferation|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of epithelial cell proliferation|
|humoral immune response|
|response to peptide hormone|
|response to peptide|
|inflammatory response|
|cell-cell adhesion|
|negative regulation of cell differentiation|
|interspecies interaction between organisms|
|response to hormone|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|response to organonitrogen compound|
|identical protein binding|
|response to nitrogen compound|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|regulation of cell differentiation|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9604
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='REG3A Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>