RELA [The Human Chemical-Genetic Interaction Map Project]

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======= RELA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RELA
  * **<color #00a2e8>Official Name</color>**: RELA proto-oncogene, NF-kB subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5970|5970]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04206|Q04206]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RELA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RELA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164014|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681). {ECO:0000269|PubMed:10928981, ECO:0000269|PubMed:12748188, ECO:0000269|PubMed:15790681, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:17620405, ECO:0000269|PubMed:19058135, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:20547752}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetaldehyde metabolic process|
|NF-kappaB p50/p65 complex|
|positive regulation of Schwann cell differentiation|
|response to cobalamin|
|RNA polymerase II transcription coactivator binding|
|regulation of Schwann cell differentiation|
|cellular response to peptidoglycan|
|ankyrin repeat binding|
|positive regulation of miRNA metabolic process|
|nucleotide-binding oligomerization domain containing 2 signaling pathway|
|positive regulation of interleukin-12 biosynthetic process|
|pri-miRNA transcription by RNA polymerase II|
|postsynapse to nucleus signaling pathway|
|cellular response to nicotine|
|regulation of interleukin-12 biosynthetic process|
|cellular response to lipoteichoic acid|
|response to lipoteichoic acid|
|regulation of miRNA metabolic process|
|negative regulation of protein sumoylation|
|response to peptidoglycan|
|phosphate ion binding|
|actinin binding|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|positive regulation of T cell receptor signaling pathway|
|cellular response to hepatocyte growth factor stimulus|
|response to UV-B|
|response to hepatocyte growth factor|
|response to muscle stretch|
|regulation of leukocyte adhesion to vascular endothelial cell|
|response to muramyl dipeptide|
|membrane protein intracellular domain proteolysis|
|cellular response to angiotensin|
|positive regulation of chondrocyte differentiation|
|regulation of protein sumoylation|
|positive regulation of antigen receptor-mediated signaling pathway|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|negative regulation of NIK/NF-kappaB signaling|
|response to angiotensin|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|NF-kappaB binding|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|cellular response to interleukin-6|
|response to morphine|
|response to isoquinoline alkaloid|
|activating transcription factor binding|
|positive regulation of cartilage development|
|negative regulation of insulin receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|positive regulation of interleukin-12 production|
|negative regulation of cellular response to insulin stimulus|
|response to interleukin-6|
|membrane protein proteolysis|
|postsynaptic signal transduction|
|repressing transcription factor binding|
|regulation of T cell receptor signaling pathway|
|cellular response to vascular endothelial growth factor stimulus|
|regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of glial cell differentiation|
|response to progesterone|
|response to nicotine|
|regulation of chondrocyte differentiation|
|cellular defense response|
|cellular aldehyde metabolic process|
|regulation of interleukin-12 production|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of insulin receptor signaling pathway|
|positive regulation of cytokine biosynthetic process|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|regulation of cartilage development|
|cellular response to hydrogen peroxide|
|hair follicle development|
|chromatin DNA binding|
|regulation of cellular response to insulin stimulus|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|positive regulation of NIK/NF-kappaB signaling|
|response to anesthetic|
|positive regulation of type I interferon production|
|NIK/NF-kappaB signaling|
|negative regulation of protein modification by small protein conjugation or removal|
|response to vitamin|
|molting cycle|
|hair cycle|
|interleukin-1-mediated signaling pathway|
|response to cAMP|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of extrinsic apoptotic signaling pathway|
|regulation of cytokine biosynthetic process|
|protein N-terminus binding|
|regulation of NIK/NF-kappaB signaling|
|histone deacetylase binding|
|stimulatory C-type lectin receptor signaling pathway|
|response to alkaloid|
|response to amino acid|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of gliogenesis|
|cellular response to antibiotic|
|tumor necrosis factor-mediated signaling pathway|
|response to hydrogen peroxide|
|liver development|
|regulation of DNA-templated transcription in response to stress|
|regulation of type I interferon production|
|pattern recognition receptor signaling pathway|
|hepaticobiliary system development|
|cellular response to reactive oxygen species|
|negative regulation of protein catabolic process|
|response to organophosphorus|
|response to UV|
|positive regulation of NF-kappaB transcription factor activity|
|response to purine-containing compound|
|regulation of extrinsic apoptotic signaling pathway|
|intracellular receptor signaling pathway|
|Fc-epsilon receptor signaling pathway|
|cellular response to interleukin-1|
|T cell receptor signaling pathway|
|response to ammonium ion|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|defense response to virus|
|cellular response to molecule of bacterial origin|
|response to ketone|
|response to reactive oxygen species|
|response to interleukin-1|
|transcription factor complex|
|response to mechanical stimulus|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|transcription regulatory region DNA binding|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|regulation of protein modification by small protein conjugation or removal|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|nuclear chromatin|
|cellular response to tumor necrosis factor|
|cellular response to oxidative stress|
|Fc receptor signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|protein-containing complex binding|
|cellular response to peptide hormone stimulus|
|aging|
|response to virus|
|ubiquitin protein ligase binding|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to light stimulus|
|negative regulation of catabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to peptide|
|response to steroid hormone|
|transcription factor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|response to acid chemical|
|enzyme binding|
|glutamatergic synapse|
|positive regulation of response to biotic stimulus|
|skin development|
|regulation of protein catabolic process|
|response to oxidative stress|
|response to peptide hormone|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|cellular response to drug|
|gland development|
|epidermis development|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of innate immune response|
|synaptic signaling|
|protein kinase binding|
|positive regulation of neurogenesis|
|response to peptide|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|response to nutrient levels|
|inflammatory response|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|immune response-activating signal transduction|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|activation of immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|chromatin organization|
|viral process|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|response to lipid|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|defense response to other organism|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|identical protein binding|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|epithelium development|
|cell-cell signaling|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.84|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11597
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RELA Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>