RFC1 [The Human Chemical-Genetic Interaction Map Project]

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======= RFC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFC1
  * **<color #00a2e8>Official Name</color>**: replication factor C subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5981|5981]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35251|P35251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102579|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA. {ECO:0000269|PubMed:8999859}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RFC1|
|BRCT|
|AAA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA clamp unloading|
|DNA clamp unloader activity|
|Elg1 RFC-like complex|
|DNA replication factor C complex|
|DNA clamp loader activity|
|error-free translesion synthesis|
|error-prone translesion synthesis|
|telomere maintenance via telomerase|
|nucleotide-excision repair, DNA gap filling|
|telomere maintenance via semi-conservative replication|
|telomere maintenance via telomere lengthening|
|RNA-dependent DNA biosynthetic process|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|nuclear DNA replication|
|enzyme activator activity|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|transcription-coupled nucleotide-excision repair|
|telomere maintenance|
|telomere organization|
|double-stranded DNA binding|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA-dependent DNA replication|
|DNA replication|
|protein domain specific binding|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|sequence-specific DNA binding|
|DNA repair|
|detection of stimulus|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.84|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.35|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.09|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.06|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.84|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.82|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.74|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.77|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.8|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.84|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.88|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.94|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.94|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.15|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.17|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.25|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.29|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.29|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.34|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.35|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.39|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.46|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|2.47|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.49|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.49|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.52|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.53|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.6|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.63|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.71|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|3.49|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.543|
|[[:human genes:l:lrr1|LRR1]]|0.506|
|[[:human genes:p:psmd11|PSMD11]]|0.504|
|[[:human genes:c:ccna2|CCNA2]]|0.485|
|[[:human genes:z:znf830|ZNF830]]|0.483|
|[[:human genes:p:psma7|PSMA7]]|0.473|
|[[:human genes:d:ddtl|DDTL]]|0.473|
|[[:human genes:c:cdt1|CDT1]]|0.47|
|[[:human genes:e:exosc4|EXOSC4]]|0.47|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.466|
|[[:human genes:m:mt1e|MT1E]]|0.46|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.449|
|[[:human genes:c:chd4|CHD4]]|0.448|
|[[:human genes:r:rpl8|RPL8]]|0.445|
|[[:human genes:c:cdc73|CDC73]]|0.441|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.439|
|[[:human genes:r:rps12|RPS12]]|0.439|
|[[:human genes:p:psmd14|PSMD14]]|0.437|
|[[:human genes:t:top1mt|TOP1MT]]|0.436|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.434|
|[[:human genes:p:polr1a|POLR1A]]|0.432|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.432|
|[[:human genes:p:prpf8|PRPF8]]|0.431|
|[[:human genes:k:kctd17|KCTD17]]|0.431|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.429|
|[[:human genes:c:chaf1a|CHAF1A]]|0.428|
|[[:human genes:p:pan2|PAN2]]|0.426|
|[[:human genes:v:vasn|VASN]]|0.426|
|[[:human genes:d:dhx38|DHX38]]|0.425|
|[[:human genes:n:nup160|NUP160]]|0.424|
|[[:human genes:t:tceb3c|TCEB3C]]|0.424|
|[[:human genes:p:psmb4|PSMB4]]|0.423|
|[[:human genes:n:napa|NAPA]]|0.42|
|[[:human genes:a:ahctf1|AHCTF1]]|0.419|
|[[:human genes:u:utp3|UTP3]]|0.417|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.417|
|[[:human genes:t:tsg101|TSG101]]|0.416|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.413|
|[[:human genes:c:copg1|COPG1]]|0.412|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.408|
|[[:human genes:p:psmd13|PSMD13]]|0.407|
|[[:human genes:r:rps28|RPS28]]|0.407|
|[[:human genes:s:smg5|SMG5]]|0.406|
|[[:human genes:c:copb1|COPB1]]|0.405|
|[[:human genes:x:xylt2|XYLT2]]|0.404|
|[[:human genes:p:psmc1|PSMC1]]|0.401|
|[[:human genes:p:psmd2|PSMD2]]|0.4|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFC1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>