RFPL3 [The Human Chemical-Genetic Interaction Map Project]

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======= RFPL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFPL3
  * **<color #00a2e8>Official Name</color>**: ret finger protein like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10738|10738]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75679|O75679]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFPL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFPL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605970|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex. {ECO:0000269|PubMed:25107902}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|RDM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.478|
|[[:human genes:c:chd4|CHD4]]|0.469|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.466|
|[[:human genes:s:syt9|SYT9]]|0.454|
|[[:human genes:c:clasp1|CLASP1]]|0.451|
|[[:human genes:d:ddtl|DDTL]]|0.45|
|[[:human genes:c:copb1|COPB1]]|0.449|
|[[:human genes:t:tfip11|TFIP11]]|0.438|
|[[:human genes:m:myo1h|MYO1H]]|0.438|
|[[:human genes:t:tceb3c|TCEB3C]]|0.431|
|[[:human genes:f:fam160a1|FAM160A1]]|0.43|
|[[:human genes:t:twistnb|TWISTNB]]|0.429|
|[[:human genes:m:med29|MED29]]|0.425|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.423|
|[[:human genes:n:npipb5|NPIPB5]]|0.422|
|[[:human genes:n:nupl1|NUPL1]]|0.421|
|[[:human genes:p:psmd11|PSMD11]]|0.419|
|[[:human genes:r:rpl14|RPL14]]|0.413|
|[[:human genes:p:psmd3|PSMD3]]|0.412|
|[[:human genes:n:napa|NAPA]]|0.412|
|[[:human genes:u:ubl5|UBL5]]|0.408|
|[[:human genes:i:igfn1|IGFN1]]|0.408|
|[[:human genes:z:zfand5|ZFAND5]]|0.408|
|[[:human genes:c:copz1|COPZ1]]|0.408|
|[[:human genes:a:atxn1|ATXN1]]|0.407|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.407|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.407|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.407|
|[[:human genes:s:supt6h|SUPT6H]]|0.406|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.403|
|[[:human genes:u:utp3|UTP3]]|0.403|
|[[:human genes:r:rpl30|RPL30]]|0.402|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFPL3 Expression in NALM6 Cells: -3.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>