RFX3 [The Human Chemical-Genetic Interaction Map Project]

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======= RFX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFX3
  * **<color #00a2e8>Official Name</color>**: regulatory factor X3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5991|5991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48380|P48380]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RFX1 trans act|
|RFX DNA binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type B pancreatic cell maturation|
|positive regulation of type B pancreatic cell development|
|glandular epithelial cell maturation|
|columnar/cuboidal epithelial cell maturation|
|regulation of type B pancreatic cell development|
|epithelial cilium movement involved in determination of left/right asymmetry|
|type B pancreatic cell development|
|epithelial cell maturation|
|glandular epithelial cell development|
|type B pancreatic cell differentiation|
|enteroendocrine cell differentiation|
|epithelial cilium movement involved in extracellular fluid movement|
|extracellular transport|
|glandular epithelial cell differentiation|
|endocrine pancreas development|
|columnar/cuboidal epithelial cell development|
|positive regulation of epithelial cell differentiation|
|cilium movement|
|pancreas development|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|columnar/cuboidal epithelial cell differentiation|
|determination of left/right symmetry|
|endocrine system development|
|determination of bilateral symmetry|
|specification of symmetry|
|anatomical structure maturation|
|regulation of epithelial cell differentiation|
|cell maturation|
|regulation of insulin secretion|
|microtubule-based transport|
|epithelial cell development|
|transcription factor complex|
|regulation of peptide hormone secretion|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|developmental maturation|
|regulation of hormone secretion|
|microtubule-based movement|
|cilium assembly|
|cilium organization|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|regulation of protein secretion|
|regulation of peptide secretion|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of hormone levels|
|positive regulation of cell development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|microtubule-based process|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|organelle assembly|
|regulation of secretion|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of protein localization|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.73|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFX3 Expression in NALM6 Cells: 4.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>