RFXANK [The Human Chemical-Genetic Interaction Map Project]

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======= RFXANK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RFXANK
  * **<color #00a2e8>Official Name</color>**: regulatory factor X associated ankyrin containing protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8625|8625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14593|O14593]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RFXANK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RFXANK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (PubMed:9806546, PubMed:10072068, PubMed:10725724). May also potentiate the activation of RAF1 (By similarity). {ECO:0000250|UniProtKB:Q9Z205, ECO:0000269|PubMed:10072068, ECO:0000269|PubMed:10725724, ECO:0000269|PubMed:9806546}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intercellular bridge|
|transcription coregulator activity|
|histone deacetylase binding|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|DNA-binding transcription factor activity|
|positive regulation of transcription by RNA polymerase II|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.74|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.74|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.548|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.538|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.536|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.525|
|[[:human genes:t:tfip11|TFIP11]]|0.518|
|[[:human genes:p:polr2j3|POLR2J3]]|0.517|
|[[:human genes:v:vasn|VASN]]|0.51|
|[[:human genes:t:twistnb|TWISTNB]]|0.499|
|[[:human genes:c:c14orf93|C14orf93]]|0.498|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.481|
|[[:human genes:k:kctd17|KCTD17]]|0.472|
|[[:human genes:a:ankle1|ANKLE1]]|0.459|
|[[:human genes:r:rrn3|RRN3]]|0.459|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.457|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.456|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.456|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.455|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.455|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.454|
|[[:human genes:m:myo1h|MYO1H]]|0.454|
|[[:human genes:t:ticrr|TICRR]]|0.447|
|[[:human genes:h:hap1|HAP1]]|0.446|
|[[:human genes:m:med17|MED17]]|0.445|
|[[:human genes:d:ddtl|DDTL]]|0.443|
|[[:human genes:s:syt9|SYT9]]|0.44|
|[[:human genes:c:copa|COPA]]|0.438|
|[[:human genes:a:akirin2|AKIRIN2]]|0.438|
|[[:human genes:s:stil|STIL]]|0.437|
|[[:human genes:t:tonsl|TONSL]]|0.437|
|[[:human genes:c:cdc45|CDC45]]|0.436|
|[[:human genes:o:orc6|ORC6]]|0.435|
|[[:human genes:p:psmb3|PSMB3]]|0.434|
|[[:human genes:a:ankle2|ANKLE2]]|0.433|
|[[:human genes:s:sfpq|SFPQ]]|0.428|
|[[:human genes:c:chd4|CHD4]]|0.427|
|[[:human genes:d:dtl|DTL]]|0.426|
|[[:human genes:c:cbwd3|CBWD3]]|0.426|
|[[:human genes:s:supt6h|SUPT6H]]|0.424|
|[[:human genes:z:znf106|ZNF106]]|0.424|
|[[:human genes:p:psmd3|PSMD3]]|0.423|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.422|
|[[:human genes:c:cbwd5|CBWD5]]|0.418|
|[[:human genes:m:mt1e|MT1E]]|0.418|
|[[:human genes:n:nol12|NOL12]]|0.414|
|[[:human genes:r:rnf4|RNF4]]|0.413|
|[[:human genes:s:sel1l|SEL1L]]|0.413|
|[[:human genes:m:myh2|MYH2]]|0.413|
|[[:human genes:m:med14|MED14]]|0.411|
|[[:human genes:r:rps12|RPS12]]|0.411|
|[[:human genes:t:trim52|TRIM52]]|0.411|
|[[:human genes:n:nupl1|NUPL1]]|0.41|
|[[:human genes:c:cgb2|CGB2]]|0.41|
|[[:human genes:o:ogfr|OGFR]]|0.41|
|[[:human genes:r:rad21|RAD21]]|0.409|
|[[:human genes:t:tyms|TYMS]]|0.407|
|[[:human genes:t:tef|TEF]]|0.407|
|[[:human genes:s:sf3a3|SF3A3]]|0.407|
|[[:human genes:t:taf12|TAF12]]|0.407|
|[[:human genes:r:rrp15|RRP15]]|0.406|
|[[:human genes:n:nop16|NOP16]]|0.406|
|[[:human genes:r:rps7|RPS7]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.404|
|[[:human genes:p:psmd7|PSMD7]]|0.403|
|[[:human genes:r:rps28|RPS28]]|0.402|
|[[:human genes:a:aaas|AAAS]]|0.402|
|[[:human genes:z:znf219|ZNF219]]|0.401|
|[[:human genes:p:psmc2|PSMC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2166
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RFXANK Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>