RGS8 [The Human Chemical-Genetic Interaction Map Project]

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======= RGS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGS8
  * **<color #00a2e8>Official Name</color>**: regulator of G protein signaling 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85397|85397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57771|P57771]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). {ECO:0000250|UniProtKB:P49804, ECO:0000269|PubMed:18434541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RGS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of dopamine receptor signaling pathway|
|G protein-coupled acetylcholine receptor signaling pathway|
|neuronal cell body membrane|
|acetylcholine receptor signaling pathway|
|response to acetylcholine|
|cellular response to acetylcholine|
|regulation of cellular response to drug|
|postsynaptic signal transduction|
|extrinsic component of cytoplasmic side of plasma membrane|
|signal transduction involved in cellular response to ammonium ion|
|regulation of response to drug|
|cellular response to ammonium ion|
|perikaryon|
|response to ammonium ion|
|GTPase activator activity|
|GTPase activity|
|cellular response to drug|
|positive regulation of GTPase activity|
|dendrite|
|synaptic signaling|
|regulation of GTPase activity|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|positive regulation of hydrolase activity|
|response to hormone|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.08|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.74|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.73|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGS8 Expression in NALM6 Cells: 1.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>