RGS9 [The Human Chemical-Genetic Interaction Map Project]

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======= RGS9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RGS9
  * **<color #00a2e8>Official Name</color>**: regulator of G protein signaling 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8787|8787]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75916|O75916]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RGS9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RGS9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604067|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-gamma|
|RGS|
|DEP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of calcium ion export across plasma membrane|
|positive regulation of NMDA glutamate receptor activity|
|positive regulation of glutamate receptor signaling pathway|
|postsynaptic density membrane|
|response to amphetamine|
|positive regulation of signaling receptor activity|
|dopamine receptor signaling pathway|
|regulation of NMDA receptor activity|
|response to amine|
|response to bronchodilator|
|regulation of glutamate receptor signaling pathway|
|positive regulation of cation channel activity|
|regulation of neurotransmitter receptor activity|
|cellular response to dopamine|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|positive regulation of ion transmembrane transporter activity|
|response to monoamine|
|response to catecholamine|
|positive regulation of transporter activity|
|cellular response to ammonium ion|
|response to estradiol|
|positive regulation of cation transmembrane transport|
|regulation of G protein-coupled receptor signaling pathway|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|response to ammonium ion|
|positive regulation of transmembrane transport|
|visual perception|
|sensory perception of light stimulus|
|protein folding|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|GTPase activator activity|
|response to xenobiotic stimulus|
|GTPase activity|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|regulation of metal ion transport|
|cellular response to drug|
|positive regulation of GTPase activity|
|regulation of ion transmembrane transport|
|regulation of GTPase activity|
|response to toxic substance|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of ion transport|
|positive regulation of hydrolase activity|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|sensory perception|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5139
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RGS9 Expression in NALM6 Cells: 2.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>