RHBDD3 [The Human Chemical-Genetic Interaction Map Project]

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======= RHBDD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHBDD3
  * **<color #00a2e8>Official Name</color>**: rhomboid domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25807|25807]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3P4|Q9Y3P4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHBDD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHBDD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rhomboid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of natural killer cell activation|
|regulation of natural killer cell activation|
|regulation of acute inflammatory response|
|liver development|
|hepaticobiliary system development|
|negative regulation of lymphocyte activation|
|serine-type endopeptidase activity|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|positive regulation of protein catabolic process|
|response to xenobiotic stimulus|
|regulation of inflammatory response|
|MAPK cascade|
|regulation of protein catabolic process|
|signal transduction by protein phosphorylation|
|gland development|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|protein phosphorylation|
|regulation of catabolic process|
|regulation of protein localization|
|regulation of response to external stimulus|
|proteolysis|
|phosphorylation|
|regulation of response to stress|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.29|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.72|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.455|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.423|
|[[:human genes:u:upf1|UPF1]]|0.409|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.407|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.404|
|[[:human genes:p:prim1|PRIM1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2294
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHBDD3 Expression in NALM6 Cells: 4.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>