RHOA [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= RHOA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOA
  * **<color #00a2e8>Official Name</color>**: ras homolog family member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387|387]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61586|P61586]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695). {ECO:0000250, ECO:0000269|PubMed:12900402, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:20974804, ECO:0000269|PubMed:8910519, ECO:0000269|PubMed:9121475, ECO:0000269|PubMed:9635436}. (Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pseudotuberculosis, which causes gastrointestinal disorders. {ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ras|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic cleavage furrow formation|
|angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure|
|endothelial tube lumen extension|
|positive regulation of vascular smooth muscle contraction|
|skeletal muscle satellite cell migration|
|Rho GDP-dissociation inhibitor binding|
|beta selection|
|Roundabout signaling pathway|
|apolipoprotein A-I-mediated signaling pathway|
|regulation of blood vessel diameter by renin-angiotensin|
|renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure|
|regulation of systemic arterial blood pressure by endothelin|
|regulation of modification of postsynaptic actin cytoskeleton|
|cleavage furrow formation|
|forebrain radial glial cell differentiation|
|negative regulation of oxidative phosphorylation|
|regulation of modification of postsynaptic structure|
|regulation of vascular smooth muscle contraction|
|cell division site|
|negative regulation of cell size|
|regulation of modification of synaptic structure|
|radial glial cell differentiation|
|positive regulation of podosome assembly|
|endothelial tube morphogenesis|
|morphogenesis of an endothelium|
|establishment or maintenance of actin cytoskeleton polarity|
|alpha-beta T cell lineage commitment|
|positive regulation of systemic arterial blood pressure|
|positive regulation of leukocyte adhesion to vascular endothelial cell|
|ossification involved in bone maturation|
|negative regulation of cell migration involved in sprouting angiogenesis|
|regulation of podosome assembly|
|establishment of epithelial cell apical/basal polarity|
|bone maturation|
|stress fiber assembly|
|contractile actin filament bundle assembly|
|establishment or maintenance of cytoskeleton polarity|
|apical junction complex|
|polarized epithelial cell differentiation|
|regulation of leukocyte adhesion to vascular endothelial cell|
|T cell lineage commitment|
|establishment of apical/basal cell polarity|
|animal organ maturation|
|mitotic cytokinetic process|
|establishment of monopolar cell polarity|
|regulation of osteoblast proliferation|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|establishment or maintenance of monopolar cell polarity|
|renal system process involved in regulation of systemic arterial blood pressure|
|negative regulation of sprouting angiogenesis|
|myosin binding|
|negative regulation of ATP metabolic process|
|wound healing, spreading of cells|
|GTP metabolic process|
|epiboly involved in wound healing|
|epiboly|
|negative regulation of reactive oxygen species biosynthetic process|
|regulation of oxidative phosphorylation|
|vasoconstriction|
|positive regulation of smooth muscle contraction|
|establishment of epithelial cell polarity|
|positive regulation of vasoconstriction|
|positive regulation of T cell migration|
|negative regulation of blood vessel endothelial cell migration|
|cytokinetic process|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|androgen receptor signaling pathway|
|positive regulation of lymphocyte migration|
|positive regulation of blood pressure|
|mitotic spindle assembly|
|regulation of systemic arterial blood pressure by hormone|
|regulation of cell migration involved in sprouting angiogenesis|
|cell periphery|
|positive regulation of cytokinesis|
|negative regulation of blood vessel diameter|
|T cell selection|
|guanosine-containing compound metabolic process|
|cerebral cortex cell migration|
|morphogenesis of a polarized epithelium|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|substantia nigra development|
|regulation of T cell migration|
|positive regulation of muscle contraction|
|negative chemotaxis|
|apical junction assembly|
|trabecula morphogenesis|
|establishment or maintenance of epithelial cell apical/basal polarity|
|positive regulation of alpha-beta T cell differentiation|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|morphogenesis of an epithelial sheet|
|establishment or maintenance of apical/basal cell polarity|
|negative regulation of endothelial cell migration|
|establishment or maintenance of bipolar cell polarity|
|alpha-beta T cell differentiation|
|positive regulation of stress fiber assembly|
|negative regulation of reactive oxygen species metabolic process|
|positive regulation of neuron apoptotic process|
|cleavage furrow|
|regulation of vasoconstriction|
|telencephalon cell migration|
|regulation of focal adhesion assembly|
|regulation of smooth muscle contraction|
|purine ribonucleoside triphosphate metabolic process|
|regulation of cell-substrate junction assembly|
|positive regulation of alpha-beta T cell activation|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of actin filament bundle assembly|
|alpha-beta T cell activation|
|forebrain cell migration|
|ficolin-1-rich granule membrane|
|purine ribonucleoside metabolic process|
|negative regulation of cell-substrate adhesion|
|regulation of alpha-beta T cell differentiation|
|neural nucleus development|
|regulation of lymphocyte migration|
|actin filament bundle assembly|
|purine nucleoside metabolic process|
|actin cytoskeleton reorganization|
|endothelial cell migration|
|forebrain generation of neurons|
|negative regulation of epithelial cell migration|
|ribonucleoside triphosphate metabolic process|
|actin filament bundle organization|
|vascular endothelial growth factor receptor signaling pathway|
|regulation of adherens junction organization|
|mitotic cytokinesis|
|intracellular steroid hormone receptor signaling pathway|
|purine nucleoside triphosphate metabolic process|
|negative regulation of axonogenesis|
|regulation of sprouting angiogenesis|
|positive regulation of blood circulation|
|positive regulation of lipase activity|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|GDP binding|
|positive regulation of organelle assembly|
|ribonucleoside metabolic process|
|mitotic spindle organization|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of NIK/NF-kappaB signaling|
|Rho protein signal transduction|
|regulation of stress fiber assembly|
|positive regulation of T cell differentiation|
|postsynapse|
|epithelial cell migration|
|regulation of reactive oxygen species biosynthetic process|
|midbrain development|
|positive regulation of axonogenesis|
|epithelium migration|
|positive regulation of cell division|
|ephrin receptor signaling pathway|
|regulation of neural precursor cell proliferation|
|regulation of cytokinesis|
|regulation of cell junction assembly|
|regulation of actomyosin structure organization|
|cellular response to chemokine|
|response to chemokine|
|regulation of blood vessel endothelial cell migration|
|positive regulation of actin filament polymerization|
|positive regulation of neuron death|
|nucleoside triphosphate metabolic process|
|regulation of actin filament bundle assembly|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|tissue migration|
|regulation of systemic arterial blood pressure|
|ruffle membrane|
|endothelium development|
|cytoskeleton-dependent cytokinesis|
|Wnt signaling pathway, planar cell polarity pathway|
|regulation of lipase activity|
|negative regulation of cell morphogenesis involved in differentiation|
|secretory granule membrane|
|cytokinesis|
|spindle assembly|
|transforming growth factor beta receptor signaling pathway|
|negative regulation of angiogenesis|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of blood vessel morphogenesis|
|cell-cell junction assembly|
|nucleoside metabolic process|
|regulation of NIK/NF-kappaB signaling|
|renal system process|
|regulation of establishment of planar polarity|
|regulation of cell-matrix adhesion|
|actomyosin structure organization|
|response to amino acid|
|negative regulation of vasculature development|
|cerebral cortex development|
|establishment of cell polarity|
|steroid hormone mediated signaling pathway|
|regulation of ATP metabolic process|
|odontogenesis|
|skeletal muscle tissue development|
|positive regulation of translation|
|cell-matrix adhesion|
|response to ethanol|
|positive regulation of protein polymerization|
|positive regulation of leukocyte migration|
|skeletal muscle organ development|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|non-canonical Wnt signaling pathway|
|glycosyl compound metabolic process|
|anatomical structure maturation|
|T cell differentiation|
|cell cortex|
|response to glucose|
|plasma membrane invagination|
|cell-cell junction organization|
|regulation of T cell differentiation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|vesicle|
|stress-activated protein kinase signaling cascade|
|response to hexose|
|membrane invagination|
|response to glucocorticoid|
|negative regulation of neuron apoptotic process|
|mitotic nuclear division|
|positive regulation of leukocyte differentiation|
|response to monosaccharide|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of cellular amide metabolic process|
|regulation of cell shape|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to transforming growth factor beta stimulus|
|spindle organization|
|regulation of endothelial cell migration|
|midbody|
|regulation of generation of precursor metabolites and energy|
|regulation of muscle contraction|
|response to corticosteroid|
|response to transforming growth factor beta|
|positive regulation of cell growth|
|intracellular receptor signaling pathway|
|regulation of actin filament polymerization|
|cell junction assembly|
|regulation of lymphocyte differentiation|
|regulation of cell division|
|vascular process in circulatory system|
|hormone-mediated signaling pathway|
|glial cell differentiation|
|ameboidal-type cell migration|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|pallium development|
|lamellipodium|
|regulation of reactive oxygen species metabolic process|
|regulation of morphogenesis of an epithelium|
|negative regulation of cell projection organization|
|regulation of cell size|
|regulation of blood pressure|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cellular response to lipopolysaccharide|
|regulation of axonogenesis|
|cell-substrate adhesion|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|regulation of microtubule cytoskeleton organization|
|cellular response to molecule of bacterial origin|
|positive regulation of peptidase activity|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|positive regulation of T cell activation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|gliogenesis|
|cell junction organization|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of epithelial cell migration|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|response to alcohol|
|regulation of muscle system process|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|T cell activation|
|lymphocyte differentiation|
|developmental maturation|
|actin filament organization|
|regulation of cysteine-type endopeptidase activity|
|protein domain specific binding|
|cell fate commitment|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of calcium ion transport|
|positive regulation of cell-cell adhesion|
|regulation of animal organ morphogenesis|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of growth|
|regulation of actin filament organization|
|ossification|
|endosome|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|protein deubiquitination|
|striated muscle tissue development|
|nuclear division|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|regulation of blood circulation|
|negative regulation of neurogenesis|
|axon|
|muscle organ development|
|muscle tissue development|
|regulation of leukocyte cell-cell adhesion|
|protein modification by small protein removal|
|response to antibiotic|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|organelle fission|
|negative regulation of nervous system development|
|purine ribonucleotide metabolic process|
|response to lipopolysaccharide|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|regulation of vasculature development|
|negative regulation of locomotion|
|ribonucleotide metabolic process|
|response to molecule of bacterial origin|
|response to steroid hormone|
|GTPase activity|
|leukocyte differentiation|
|purine nucleotide metabolic process|
|negative regulation of cell development|
|ribose phosphate metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|response to acid chemical|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|regulation of translation|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|response to decreased oxygen levels|
|positive regulation of lymphocyte activation|
|cytoskeleton|
|positive regulation of neuron differentiation|
|purine-containing compound metabolic process|
|positive regulation of cell cycle|
|regulation of cellular component size|
|response to oxygen levels|
|positive regulation of cell projection organization|
|lymphocyte activation|
|forebrain development|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|GTP binding|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|focal adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|negative regulation of phosphorylation|
|regulation of peptidase activity|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of protein complex assembly|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|protein kinase binding|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|cell division|
|actin cytoskeleton organization|
|skeletal system development|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|leukocyte degranulation|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|nucleobase-containing small molecule metabolic process|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|cell junction|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|regulation of system process|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|microtubule-based process|
|regulation of growth|
|regulation of cell adhesion|
|epithelial cell differentiation|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|viral process|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of proteolysis|
|brain development|
|regulation of cell cycle process|
|organelle assembly|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-3.6|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-3.52|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.44|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-3.18|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-3.1|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-3.06|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-3.03|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-3.01|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.9|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.9|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.84|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.81|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.76|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.68|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.67|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.67|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.65|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.63|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.61|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.51|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.48|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.45|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.44|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.43|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.41|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.38|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.37|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.37|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.37|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.33|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.28|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.27|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.26|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.23|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.23|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.22|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.16|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.16|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.12|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.12|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.06|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.01|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-2.01|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.98|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.88|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.88|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.85|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.84|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.83|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.81|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.8|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.79|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.78|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.76|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.75|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.74|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.72|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.82|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.98|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.01|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.23|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.31|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.48|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.88|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|5.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gna13|GNA13]]|0.676|
|[[:human genes:a:arhgef1|ARHGEF1]]|0.561|
|[[:human genes:r:ric8a|RIC8A]]|0.515|
|[[:human genes:s:strada|STRADA]]|0.479|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 68/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|11/28|
|bone|1/26|
|breast|3/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|6/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6072
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOA Expression in NALM6 Cells: 8.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>