RHOBTB1 [The Human Chemical-Genetic Interaction Map Project]

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======= RHOBTB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RHOBTB1
  * **<color #00a2e8>Official Name</color>**: Rho related BTB domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9886|9886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94844|O94844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RHOBTB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RHOBTB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|engulfment of apoptotic cell|
|apoptotic cell clearance|
|actin cytoskeleton reorganization|
|Rho protein signal transduction|
|positive regulation of actin filament polymerization|
|cell projection|
|positive regulation of protein polymerization|
|phagocytosis, engulfment|
|plasma membrane invagination|
|membrane invagination|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|small GTPase mediated signal transduction|
|phagocytosis|
|GTPase activity|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|regulation of cellular component size|
|regulation of actin filament-based process|
|GTP binding|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|protein kinase binding|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|positive regulation of organelle organization|
|import into cell|
|cell morphogenesis|
|cellular component morphogenesis|
|membrane organization|
|regulation of cellular component biogenesis|
|cell migration|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|movement of cell or subcellular component|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.64|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.43|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.07|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.72|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.73|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.19|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.55|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18208
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RHOBTB1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>