RIMKLB [The Human Chemical-Genetic Interaction Map Project]

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======= RIMKLB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIMKLB
  * **<color #00a2e8>Official Name</color>**: ribosomal modification protein rimK like family member B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57494|57494]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULI2|Q9ULI2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIMKLB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIMKLB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. {ECO:0000250|UniProtKB:Q80WS1}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-grasp 3|
|RimK|
|GSH-S ATP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|citrate-L-glutamate ligase activity|
|N-acetyl-L-aspartate-L-glutamate ligase activity|
|cellular amino acid biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.73|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.72|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.75|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.87|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.26|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIMKLB Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>