RIOK1 [The Human Chemical-Genetic Interaction Map Project]

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======= RIOK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIOK1
  * **<color #00a2e8>Official Name</color>**: RIO kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83732|83732]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRS2|Q9BRS2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RIOK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RIOK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617753|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre- rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:22072790}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIO1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methyltransferase complex|
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|regulation of rRNA processing|
|preribosome, small subunit precursor|
|regulation of ribosome biogenesis|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|hydrolase activity|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|protein serine/threonine kinase activity|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|RNA processing|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|phosphorylation|
|ATP binding|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.78|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.444|
|[[:human genes:r:rbbp6|RBBP6]]|0.415|
|[[:human genes:p:psmd7|PSMD7]]|0.407|
|[[:human genes:r:rps12|RPS12]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 352/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|19/28|
|bone|9/26|
|breast|12/33|
|central nervous system|23/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|11/21|
|liver|11/20|
|lung|38/75|
|lymphocyte|4/16|
|ovary|14/26|
|pancreas|18/24|
|peripheral nervous system|7/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|9/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|12/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 970
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RIOK1 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>