RNASEH1 [The Human Chemical-Genetic Interaction Map Project]

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======= RNASEH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNASEH1
  * **<color #00a2e8>Official Name</color>**: ribonuclease H1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=246243|246243]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60930|O60930]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNASEH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNASEH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604123|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that are directed to the mitochondria or to the nucleus. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF). Mutations in this gene have been found in individuals with progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2. Alternative splicing results in additional coding and non-coding transcript variants. Pseudogenes of this gene have been defined on chromosomes 2 and 17. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (PubMed:10497183). Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II (PubMed:21700224). {ECO:0000269|PubMed:10497183, ECO:0000269|PubMed:21700224}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNase H|
|Cauli VI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication, removal of RNA primer|
|RNA-DNA hybrid ribonuclease activity|
|ribonuclease activity|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|nucleic acid binding|
|magnesium ion binding|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA metabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.25|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-2.03|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.74|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.71|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.71|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.81|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.87|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.91|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.95|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.96|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.99|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.06|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.07|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.09|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.1|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.11|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.17|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.31|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.36|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.36|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.6|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.63|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.87|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:selrc1|SELRC1]]|0.671|
|[[:human genes:y:yars2|YARS2]]|0.661|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.647|
|[[:human genes:r:rpusd4|RPUSD4]]|0.645|
|[[:human genes:c:c17orf89|C17orf89]]|0.645|
|[[:human genes:r:rbfa|RBFA]]|0.64|
|[[:human genes:t:tars2|TARS2]]|0.639|
|[[:human genes:c:c12orf65|C12orf65]]|0.637|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.625|
|[[:human genes:m:mrpl21|MRPL21]]|0.622|
|[[:human genes:n:ndufb5|NDUFB5]]|0.616|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.613|
|[[:human genes:m:mrps5|MRPS5]]|0.607|
|[[:human genes:b:bcs1l|BCS1L]]|0.607|
|[[:human genes:n:ndufb11|NDUFB11]]|0.607|
|[[:human genes:m:mrps6|MRPS6]]|0.605|
|[[:human genes:s:sco2|SCO2]]|0.597|
|[[:human genes:m:mrps16|MRPS16]]|0.597|
|[[:human genes:q:qrsl1|QRSL1]]|0.595|
|[[:human genes:m:mrps21|MRPS21]]|0.59|
|[[:human genes:n:ndufa3|NDUFA3]]|0.589|
|[[:human genes:g:gatc|GATC]]|0.588|
|[[:human genes:g:gfm1|GFM1]]|0.587|
|[[:human genes:p:polg2|POLG2]]|0.586|
|[[:human genes:m:mrps34|MRPS34]]|0.584|
|[[:human genes:g:gfm2|GFM2]]|0.582|
|[[:human genes:n:nars2|NARS2]]|0.582|
|[[:human genes:f:fastkd5|FASTKD5]]|0.577|
|[[:human genes:s:sars2|SARS2]]|0.576|
|[[:human genes:e:ears2|EARS2]]|0.575|
|[[:human genes:p:pars2|PARS2]]|0.573|
|[[:human genes:d:dap3|DAP3]]|0.569|
|[[:human genes:m:mrpl23|MRPL23]]|0.568|
|[[:human genes:m:mrpl53|MRPL53]]|0.566|
|[[:human genes:m:mrpl12|MRPL12]]|0.565|
|[[:human genes:m:mrp63|MRP63]]|0.557|
|[[:human genes:v:vars2|VARS2]]|0.557|
|[[:human genes:c:cox16|COX16]]|0.554|
|[[:human genes:m:mipep|MIPEP]]|0.554|
|[[:human genes:c:cox6c|COX6C]]|0.553|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.552|
|[[:human genes:t:tefm|TEFM]]|0.552|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.551|
|[[:human genes:c:c10orf2|C10orf2]]|0.55|
|[[:human genes:m:mtg2|MTG2]]|0.549|
|[[:human genes:t:tmem242|TMEM242]]|0.549|
|[[:human genes:c:coq2|COQ2]]|0.543|
|[[:human genes:m:mrps14|MRPS14]]|0.543|
|[[:human genes:d:dars2|DARS2]]|0.54|
|[[:human genes:s:slc25a26|SLC25A26]]|0.538|
|[[:human genes:l:lars2|LARS2]]|0.538|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.536|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.536|
|[[:human genes:f:ftsj2|FTSJ2]]|0.535|
|[[:human genes:c:coa6|COA6]]|0.533|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.531|
|[[:human genes:m:mrps9|MRPS9]]|0.531|
|[[:human genes:n:ndufs7|NDUFS7]]|0.529|
|[[:human genes:w:wars2|WARS2]]|0.529|
|[[:human genes:n:ndufb6|NDUFB6]]|0.528|
|[[:human genes:e:ecsit|ECSIT]]|0.528|
|[[:human genes:w:wbscr16|WBSCR16]]|0.527|
|[[:human genes:t:tmem126b|TMEM126B]]|0.526|
|[[:human genes:f:fars2|FARS2]]|0.525|
|[[:human genes:m:mrps24|MRPS24]]|0.524|
|[[:human genes:m:mrps2|MRPS2]]|0.524|
|[[:human genes:m:mrps10|MRPS10]]|0.524|
|[[:human genes:m:mrpl15|MRPL15]]|0.524|
|[[:human genes:r:rars2|RARS2]]|0.523|
|[[:human genes:p:polg|POLG]]|0.521|
|[[:human genes:m:mrps18a|MRPS18A]]|0.521|
|[[:human genes:m:mtg1|MTG1]]|0.521|
|[[:human genes:m:mrps26|MRPS26]]|0.515|
|[[:human genes:m:mrps25|MRPS25]]|0.514|
|[[:human genes:m:mrpl47|MRPL47]]|0.507|
|[[:human genes:t:tomm20|TOMM20]]|0.505|
|[[:human genes:a:aifm1|AIFM1]]|0.503|
|[[:human genes:t:trub2|TRUB2]]|0.501|
|[[:human genes:a:atp5sl|ATP5SL]]|0.498|
|[[:human genes:n:ndufa1|NDUFA1]]|0.496|
|[[:human genes:r:rpia|RPIA]]|0.496|
|[[:human genes:t:tufm|TUFM]]|0.493|
|[[:human genes:n:ndufs2|NDUFS2]]|0.49|
|[[:human genes:c:coa3|COA3]]|0.488|
|[[:human genes:n:ndufc2|NDUFC2]]|0.488|
|[[:human genes:c:coq3|COQ3]]|0.487|
|[[:human genes:c:cox5a|COX5A]]|0.487|
|[[:human genes:g:grsf1|GRSF1]]|0.486|
|[[:human genes:c:chchd4|CHCHD4]]|0.485|
|[[:human genes:n:ndufa2|NDUFA2]]|0.484|
|[[:human genes:m:mrps11|MRPS11]]|0.483|
|[[:human genes:p:pdss1|PDSS1]]|0.482|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.482|
|[[:human genes:r:rpusd3|RPUSD3]]|0.481|
|[[:human genes:m:mars2|MARS2]]|0.48|
|[[:human genes:f:fh|FH]]|0.479|
|[[:human genes:d:dhx30|DHX30]]|0.479|
|[[:human genes:c:cox7b|COX7B]]|0.478|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.477|
|[[:human genes:m:mtpap|MTPAP]]|0.476|
|[[:human genes:m:mtif3|MTIF3]]|0.476|
|[[:human genes:t:triap1|TRIAP1]]|0.475|
|[[:human genes:p:pet112|PET112]]|0.473|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.472|
|[[:human genes:t:timm8b|TIMM8B]]|0.471|
|[[:human genes:p:pnpt1|PNPT1]]|0.471|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.469|
|[[:human genes:i:iba57|IBA57]]|0.468|
|[[:human genes:m:mcat|MCAT]]|0.468|
|[[:human genes:h:hars2|HARS2]]|0.467|
|[[:human genes:t:tmem261|TMEM261]]|0.463|
|[[:human genes:e:elac2|ELAC2]]|0.462|
|[[:human genes:a:acad9|ACAD9]]|0.462|
|[[:human genes:m:mterfd2|MTERFD2]]|0.46|
|[[:human genes:t:thg1l|THG1L]]|0.46|
|[[:human genes:d:dhrsx|DHRSX]]|0.46|
|[[:human genes:m:mrpl20|MRPL20]]|0.46|
|[[:human genes:a:atxn10|ATXN10]]|0.459|
|[[:human genes:n:nfu1|NFU1]]|0.459|
|[[:human genes:m:mrps33|MRPS33]]|0.457|
|[[:human genes:n:ndufs8|NDUFS8]]|0.457|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.457|
|[[:human genes:n:ndufb9|NDUFB9]]|0.457|
|[[:human genes:p:pet117|PET117]]|0.456|
|[[:human genes:c:cox15|COX15]]|0.456|
|[[:human genes:c:cox11|COX11]]|0.455|
|[[:human genes:c:chchd1|CHCHD1]]|0.455|
|[[:human genes:l:lsm10|LSM10]]|0.455|
|[[:human genes:m:mrpl45|MRPL45]]|0.454|
|[[:human genes:a:aars2|AARS2]]|0.453|
|[[:human genes:t:ten1|TEN1]]|0.452|
|[[:human genes:n:ndufa11|NDUFA11]]|0.452|
|[[:human genes:d:dnlz|DNLZ]]|0.45|
|[[:human genes:m:mettl17|METTL17]]|0.45|
|[[:human genes:s:ssb|SSB]]|0.45|
|[[:human genes:p:pgm3|PGM3]]|0.45|
|[[:human genes:t:tpk1|TPK1]]|0.449|
|[[:human genes:t:trmt61a|TRMT61A]]|0.449|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.446|
|[[:human genes:m:mrpl22|MRPL22]]|0.445|
|[[:human genes:a:atp5d|ATP5D]]|0.445|
|[[:human genes:s:slc25a19|SLC25A19]]|0.445|
|[[:human genes:f:foxred1|FOXRED1]]|0.444|
|[[:human genes:m:mto1|MTO1]]|0.444|
|[[:human genes:m:mrps23|MRPS23]]|0.442|
|[[:human genes:g:gemin7|GEMIN7]]|0.442|
|[[:human genes:l:lrpprc|LRPPRC]]|0.44|
|[[:human genes:m:mrpl44|MRPL44]]|0.44|
|[[:human genes:c:cars2|CARS2]]|0.44|
|[[:human genes:m:mrpl55|MRPL55]]|0.44|
|[[:human genes:m:mrpl46|MRPL46]]|0.438|
|[[:human genes:n:ndufa10|NDUFA10]]|0.438|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.435|
|[[:human genes:n:ndufs5|NDUFS5]]|0.434|
|[[:human genes:m:mrps12|MRPS12]]|0.434|
|[[:human genes:m:mrpl11|MRPL11]]|0.434|
|[[:human genes:t:tomm22|TOMM22]]|0.434|
|[[:human genes:g:glrx5|GLRX5]]|0.434|
|[[:human genes:f:fastkd1|FASTKD1]]|0.431|
|[[:human genes:c:cox17|COX17]]|0.431|
|[[:human genes:d:ddx28|DDX28]]|0.431|
|[[:human genes:u:uqcr10|UQCR10]]|0.431|
|[[:human genes:u:uqcc2|UQCC2]]|0.43|
|[[:human genes:u:uqcrq|UQCRQ]]|0.429|
|[[:human genes:c:coq7|COQ7]]|0.429|
|[[:human genes:t:tomm6|TOMM6]]|0.428|
|[[:human genes:p:polrmt|POLRMT]]|0.428|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.427|
|[[:human genes:m:mrpl27|MRPL27]]|0.426|
|[[:human genes:n:ndufv1|NDUFV1]]|0.426|
|[[:human genes:t:tomm40|TOMM40]]|0.424|
|[[:human genes:a:angel2|ANGEL2]]|0.424|
|[[:human genes:n:ndufb1|NDUFB1]]|0.423|
|[[:human genes:e:eif3f|EIF3F]]|0.422|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.422|
|[[:human genes:h:hccs|HCCS]]|0.421|
|[[:human genes:f:fastkd2|FASTKD2]]|0.419|
|[[:human genes:n:ndufb2|NDUFB2]]|0.418|
|[[:human genes:p:pitrm1|PITRM1]]|0.418|
|[[:human genes:a:alas1|ALAS1]]|0.418|
|[[:human genes:h:higd2a|HIGD2A]]|0.417|
|[[:human genes:r:rpe|RPE]]|0.417|
|[[:human genes:m:mrpl32|MRPL32]]|0.416|
|[[:human genes:m:mrpl4|MRPL4]]|0.416|
|[[:human genes:t:ttc4|TTC4]]|0.415|
|[[:human genes:m:mrpl2|MRPL2]]|0.415|
|[[:human genes:v:vezt|VEZT]]|0.414|
|[[:human genes:d:ddx39a|DDX39A]]|0.414|
|[[:human genes:g:g6pd|G6PD]]|0.413|
|[[:human genes:c:coq6|COQ6]]|0.412|
|[[:human genes:m:mrpl42|MRPL42]]|0.412|
|[[:human genes:n:ndufb3|NDUFB3]]|0.408|
|[[:human genes:m:mrpl43|MRPL43]]|0.407|
|[[:human genes:z:znhit1|ZNHIT1]]|0.407|
|[[:human genes:f:fam195a|FAM195A]]|0.407|
|[[:human genes:u:urm1|URM1]]|0.404|
|[[:human genes:a:atp5a1|ATP5A1]]|0.403|
|[[:human genes:s:ssbp1|SSBP1]]|0.403|
|[[:human genes:p:ppcs|PPCS]]|0.403|
|[[:human genes:n:ndufa8|NDUFA8]]|0.403|
|[[:human genes:m:malsu1|MALSU1]]|0.402|
|[[:human genes:a:alg13|ALG13]]|0.401|
|[[:human genes:m:mrpl41|MRPL41]]|0.401|
|[[:human genes:m:mterfd1|MTERFD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNASEH1 Expression in NALM6 Cells: 5.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>