RNASEL [The Human Chemical-Genetic Interaction Map Project]

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======= RNASEL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNASEL
  * **<color #00a2e8>Official Name</color>**: ribonuclease L
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6041|6041]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05823|Q05823]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNASEL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNASEL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:26263979}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Ribonuc 2-5A|
|Pkinase|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoribonuclease activity|
|ribonucleoprotein complex binding|
|regulation of type I interferon-mediated signaling pathway|
|rRNA binding|
|positive regulation of glucose import|
|positive regulation of glucose transmembrane transport|
|regulation of glucose import|
|negative regulation of viral genome replication|
|cellular response to type I interferon|
|type I interferon signaling pathway|
|response to type I interferon|
|regulation of glucose transmembrane transport|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|negative regulation of viral life cycle|
|regulation of viral genome replication|
|negative regulation of viral process|
|fat cell differentiation|
|nuclear matrix|
|regulation of viral life cycle|
|RNA phosphodiester bond hydrolysis|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of mRNA stability|
|regulation of RNA stability|
|defense response to virus|
|regulation of mRNA catabolic process|
|positive regulation of transmembrane transport|
|regulation of viral process|
|rRNA processing|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|rRNA metabolic process|
|protein kinase activity|
|response to virus|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|regulation of mRNA metabolic process|
|mitochondrial matrix|
|ncRNA processing|
|cellular component|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|regulation of transmembrane transport|
|cytokine-mediated signaling pathway|
|mRNA metabolic process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|RNA processing|
|defense response to other organism|
|protein phosphorylation|
|positive regulation of transport|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|regulation of immune response|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|regulation of response to stress|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNASEL Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>