RND1 [The Human Chemical-Genetic Interaction Map Project]

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======= RND1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RND1
  * **<color #00a2e8>Official Name</color>**: Rho family GTPase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27289|27289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92730|Q92730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RND1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RND1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609038|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. {ECO:0000269|PubMed:11095956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell division site|
|neuron remodeling|
|establishment or maintenance of actin cytoskeleton polarity|
|establishment or maintenance of cytoskeleton polarity|
|neuron maturation|
|adherens junction|
|actin filament bundle assembly|
|actin filament bundle organization|
|Rho protein signal transduction|
|anatomical structure maturation|
|cell cortex|
|regulation of cell shape|
|cell maturation|
|establishment or maintenance of cell polarity|
|actin cytoskeleton|
|developmental maturation|
|actin filament organization|
|Ras protein signal transduction|
|negative regulation of cell adhesion|
|small GTPase mediated signal transduction|
|GTPase activity|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|GTP binding|
|supramolecular fiber organization|
|protein kinase binding|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|regulation of cytoskeleton organization|
|actin filament-based process|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|neuron development|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of organelle organization|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.07|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.73|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.77|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12516
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RND1 Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>