RNF112 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF112 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF112
  * **<color #00a2e8>Official Name</color>**: ring finger protein 112
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7732|7732]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULX5|Q9ULX5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF112&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF112|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell death in response to hydrogen peroxide|
|embryonic brain development|
|cell death in response to oxidative stress|
|response to hydroperoxide|
|positive regulation of glial cell differentiation|
|endoplasmic reticulum organization|
|protein self-association|
|extrinsic component of membrane|
|protein autoubiquitination|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|cellular response to hydrogen peroxide|
|cell body|
|positive regulation of cell cycle arrest|
|regulation of cell cycle arrest|
|regulation of gliogenesis|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|synaptic vesicle|
|cellular response to reactive oxygen species|
|cell cycle arrest|
|response to reactive oxygen species|
|postsynaptic membrane|
|cellular response to toxic substance|
|ubiquitin protein ligase activity|
|cellular response to oxidative stress|
|postsynaptic density|
|endosome|
|nuclear body|
|positive regulation of cell cycle process|
|response to antibiotic|
|GTPase activity|
|protein homooligomerization|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|response to oxidative stress|
|GTP binding|
|cellular response to drug|
|endomembrane system organization|
|embryonic organ development|
|positive regulation of neurogenesis|
|response to toxic substance|
|protein complex oligomerization|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|negative regulation of cell cycle|
|regulation of neuron differentiation|
|protein ubiquitination|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|cell death|
|regulation of cell cycle|
|cell cycle|
|positive regulation of developmental process|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|neurogenesis|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.87|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.03|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3365
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF112 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>