RNF14 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF14
  * **<color #00a2e8>Official Name</color>**: ring finger protein 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9604|9604]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBS8|Q9UBS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RWD|
|IBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-like protein transferase activity|
|regulation of androgen receptor signaling pathway|
|ubiquitin conjugating enzyme binding|
|androgen receptor signaling pathway|
|androgen receptor binding|
|intracellular steroid hormone receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|ubiquitin ligase complex|
|steroid hormone mediated signaling pathway|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of proteasomal protein catabolic process|
|cellular response to steroid hormone stimulus|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|ubiquitin protein ligase activity|
|regulation of cellular protein catabolic process|
|transcription coactivator activity|
|protein polyubiquitination|
|response to steroid hormone|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|cellular response to lipid|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|response to lipid|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cellular response to endogenous stimulus|
|proteolysis|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.8|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.82|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.92|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.96|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.552|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3118
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF14 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>