RNF152 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF152 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF152
  * **<color #00a2e8>Official Name</color>**: ring finger protein 152
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220441|220441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N8N0|Q8N8N0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF152&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF152|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). {ECO:0000269|PubMed:21203937, ECO:0000269|PubMed:25936802}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integral component of organelle membrane|
|negative regulation of TORC1 signaling|
|small GTPase binding|
|protein K63-linked ubiquitination|
|regulation of TORC1 signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|protein K48-linked ubiquitination|
|regulation of TOR signaling|
|positive regulation of autophagy|
|cellular response to starvation|
|response to starvation|
|ubiquitin protein ligase activity|
|cellular response to nutrient levels|
|ubiquitin-protein transferase activity|
|lysosome|
|cellular response to extracellular stimulus|
|protein polyubiquitination|
|lysosomal membrane|
|regulation of autophagy|
|cellular response to external stimulus|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|response to nutrient levels|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|protein ubiquitination|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|programmed cell death|
|cell death|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12574
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF152 Expression in NALM6 Cells: 1.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>