RNF207 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF207 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF207
  * **<color #00a2e8>Official Name</color>**: ring finger protein 207
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388591|388591]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6ZRF8|Q6ZRF8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF207&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF207|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616923|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. {ECO:0000269|PubMed:25281747}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|
|positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|
|regulation of heart looping|
|positive regulation of atrial cardiac muscle cell action potential|
|positive regulation of membrane repolarization during cardiac muscle cell action potential|
|positive regulation of ventricular cardiac muscle cell action potential|
|positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|positive regulation of cardiac conduction|
|positive regulation of actin filament-based movement|
|positive regulation of delayed rectifier potassium channel activity|
|regulation of membrane repolarization during ventricular cardiac muscle cell action potential|
|positive regulation of cardiac muscle cell contraction|
|regulation of membrane repolarization during cardiac muscle cell action potential|
|regulation of atrial cardiac muscle cell action potential|
|regulation of membrane repolarization during action potential|
|positive regulation of action potential|
|positive regulation of cardiac muscle contraction|
|positive regulation of striated muscle contraction|
|regulation of ventricular cardiac muscle cell action potential|
|positive regulation of voltage-gated potassium channel activity|
|regulation of delayed rectifier potassium channel activity|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|positive regulation of potassium ion transmembrane transporter activity|
|regulation of cardiac muscle cell membrane repolarization|
|cell-cell signaling involved in cardiac conduction|
|regulation of cardiac muscle cell action potential|
|regulation of membrane repolarization|
|regulation of cardiac muscle cell contraction|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of heart contraction|
|regulation of heart morphogenesis|
|regulation of actin filament-based movement|
|Hsp70 protein binding|
|cell communication involved in cardiac conduction|
|positive regulation of muscle contraction|
|positive regulation of potassium ion transport|
|regulation of action potential|
|regulation of potassium ion transmembrane transporter activity|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of blood circulation|
|regulation of cardiac muscle contraction|
|regulation of potassium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of potassium ion transport|
|chaperone binding|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|ion channel binding|
|regulation of embryonic development|
|multicellular organismal signaling|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|regulation of morphogenesis of an epithelium|
|positive regulation of transmembrane transport|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of ion transmembrane transporter activity|
|regulation of animal organ morphogenesis|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|positive regulation of cellular component movement|
|regulation of transmembrane transport|
|regulation of system process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|zinc ion binding|
|positive regulation of transport|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.93|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.71|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF207 Expression in NALM6 Cells: 2.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>