RNF41 [The Human Chemical-Genetic Interaction Map Project]

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======= RNF41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNF41
  * **<color #00a2e8>Official Name</color>**: ring finger protein 41
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10193|10193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4P4|Q9H4P4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNF41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNF41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620051|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor- independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {ECO:0000250, ECO:0000250|UniProtKB:Q8BH75, ECO:0000269|PubMed:12411582, ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15632191, ECO:0000269|PubMed:17210635, ECO:0000269|PubMed:18541373, ECO:0000269|PubMed:19483718, ECO:0000269|PubMed:24949970}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|Sina|
|USP8 interact|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-3 receptor binding|
|erythropoietin receptor binding|
|negative regulation of mitophagy|
|negative regulation of autophagy of mitochondrion|
|Ral GTPase binding|
|endoplasmic reticulum tubular network|
|regulation of mitophagy|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|negative regulation of macroautophagy|
|regulation of autophagy of mitochondrion|
|negative regulation of mitochondrion organization|
|receptor tyrosine kinase binding|
|protein autoubiquitination|
|negative regulation of autophagy|
|positive regulation of reactive oxygen species metabolic process|
|extrinsic apoptotic signaling pathway|
|regulation of lymphocyte differentiation|
|regulation of macroautophagy|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|positive regulation of protein catabolic process|
|regulation of protein kinase B signaling|
|ubiquitin protein ligase activity|
|regulation of myeloid cell differentiation|
|protein domain specific binding|
|ubiquitin-protein transferase activity|
|negative regulation of cellular catabolic process|
|negative regulation of cell migration|
|positive regulation of DNA-binding transcription factor activity|
|autophagy|
|process utilizing autophagic mechanism|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|apoptotic signaling pathway|
|protein polyubiquitination|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|negative regulation of locomotion|
|regulation of autophagy|
|proteasomal protein catabolic process|
|negative regulation of organelle organization|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|proteolysis involved in cellular protein catabolic process|
|regulation of leukocyte activation|
|cellular protein catabolic process|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|protein catabolic process|
|protein ubiquitination|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of MAPK cascade|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|zinc ion binding|
|regulation of cell migration|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|apoptotic process|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of cellular component movement|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|proteolysis|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12196
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNF41 Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>