RNPC3 [The Human Chemical-Genetic Interaction Map Project]

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======= RNPC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RNPC3
  * **<color #00a2e8>Official Name</color>**: RNA binding region (RNP1, RRM) containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55599|55599]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96LT9|Q96LT9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNPC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNPC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618016|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. {ECO:0000269|PubMed:16096647, ECO:0000269|PubMed:19447915}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U12 snRNA binding|
|pre-mRNA intronic binding|
|U12-type spliceosomal complex|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.04|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.71|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.9|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd3|CBWD3]]|0.526|
|[[:human genes:c:cbwd5|CBWD5]]|0.512|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.511|
|[[:human genes:d:ddtl|DDTL]]|0.509|
|[[:human genes:p:polr2d|POLR2D]]|0.508|
|[[:human genes:z:zfand5|ZFAND5]]|0.507|
|[[:human genes:c:chd4|CHD4]]|0.504|
|[[:human genes:c:cbwd6|CBWD6]]|0.501|
|[[:human genes:p:psmb4|PSMB4]]|0.487|
|[[:human genes:e:exosc9|EXOSC9]]|0.485|
|[[:human genes:t:tceb3c|TCEB3C]]|0.485|
|[[:human genes:s:slc6a17|SLC6A17]]|0.47|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.468|
|[[:human genes:s:supt6h|SUPT6H]]|0.467|
|[[:human genes:r:rps12|RPS12]]|0.461|
|[[:human genes:c:ccna2|CCNA2]]|0.459|
|[[:human genes:v:vps28|VPS28]]|0.458|
|[[:human genes:p:psmc2|PSMC2]]|0.457|
|[[:human genes:p:psma6|PSMA6]]|0.457|
|[[:human genes:r:rpl35|RPL35]]|0.454|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.448|
|[[:human genes:i:ik|IK]]|0.448|
|[[:human genes:s:sap30bp|SAP30BP]]|0.447|
|[[:human genes:k:kctd17|KCTD17]]|0.446|
|[[:human genes:n:npipb5|NPIPB5]]|0.445|
|[[:human genes:p:psmc6|PSMC6]]|0.444|
|[[:human genes:c:cdc6|CDC6]]|0.443|
|[[:human genes:n:nsf|NSF]]|0.44|
|[[:human genes:t:twistnb|TWISTNB]]|0.439|
|[[:human genes:v:vasn|VASN]]|0.438|
|[[:human genes:n:nol10|NOL10]]|0.437|
|[[:human genes:r:ranbp2|RANBP2]]|0.436|
|[[:human genes:c:ctage4|CTAGE4]]|0.434|
|[[:human genes:c:copg1|COPG1]]|0.434|
|[[:human genes:n:nup85|NUP85]]|0.432|
|[[:human genes:c:c14orf93|C14orf93]]|0.429|
|[[:human genes:s:slc38a7|SLC38A7]]|0.428|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.427|
|[[:human genes:r:rrp7a|RRP7A]]|0.427|
|[[:human genes:p:psmd2|PSMD2]]|0.426|
|[[:human genes:s:supt5h|SUPT5H]]|0.426|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.425|
|[[:human genes:p:psmd6|PSMD6]]|0.423|
|[[:human genes:p:polr2h|POLR2H]]|0.421|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.421|
|[[:human genes:r:rbm39|RBM39]]|0.42|
|[[:human genes:l:lad1|LAD1]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.418|
|[[:human genes:r:rad21|RAD21]]|0.417|
|[[:human genes:m:mt1e|MT1E]]|0.416|
|[[:human genes:a:aatf|AATF]]|0.415|
|[[:human genes:p:psma7|PSMA7]]|0.415|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.414|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.414|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.414|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.414|
|[[:human genes:u:upf1|UPF1]]|0.413|
|[[:human genes:p:pan3|PAN3]]|0.41|
|[[:human genes:m:mtch2|MTCH2]]|0.41|
|[[:human genes:c:cep192|CEP192]]|0.409|
|[[:human genes:p:pola1|POLA1]]|0.408|
|[[:human genes:r:rps2|RPS2]]|0.408|
|[[:human genes:d:disp2|DISP2]]|0.408|
|[[:human genes:d:dock6|DOCK6]]|0.408|
|[[:human genes:s:smg1|SMG1]]|0.407|
|[[:human genes:m:myh7b|MYH7B]]|0.407|
|[[:human genes:c:cdc45|CDC45]]|0.405|
|[[:human genes:r:rad51|RAD51]]|0.404|
|[[:human genes:w:wdr43|WDR43]]|0.403|
|[[:human genes:s:setd1a|SETD1A]]|0.403|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.403|
|[[:human genes:p:psmb3|PSMB3]]|0.403|
|[[:human genes:p:psmb2|PSMB2]]|0.401|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.401|
|[[:human genes:g:golga8j|GOLGA8J]]|0.401|
|[[:human genes:a:aamp|AAMP]]|0.401|
|[[:human genes:p:paf1|PAF1]]|0.401|
|[[:human genes:m:med15|MED15]]|0.4|
|[[:human genes:n:nupl1|NUPL1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RNPC3 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>