RPAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= RPAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPAP2
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II associated protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79871|79871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXW5|Q8IXW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611476|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580, ECO:0000269|PubMed:24997600}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPAP2 Rtr1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase core enzyme binding|
|dephosphorylation of RNA polymerase II C-terminal domain|
|RNA polymerase II CTD heptapeptide repeat phosphatase activity|
|RNA polymerase II, holoenzyme|
|protein serine/threonine phosphatase activity|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|protein dephosphorylation|
|dephosphorylation|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.87|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.84|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 383/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|17/28|
|bone|9/26|
|breast|16/33|
|central nervous system|22/56|
|cervix|1/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|6/21|
|liver|9/20|
|lung|46/75|
|lymphocyte|12/16|
|ovary|14/26|
|pancreas|14/24|
|peripheral nervous system|9/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|11/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPAP2 Expression in NALM6 Cells: 7.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>