RPAP3 [The Human Chemical-Genetic Interaction Map Project]

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======= RPAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPAP3
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79657|79657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6T3|Q9H6T3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611477|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. {ECO:0000269|PubMed:17643375}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
|TPR 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|R2TP complex|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.85|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.79|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.75|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.73|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.71|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.73|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.78|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.83|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.95|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.98|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 99/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|4/26|
|breast|5/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|0/21|
|liver|2/20|
|lung|5/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPAP3 Expression in NALM6 Cells: 5.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>