RPF2 [The Human Chemical-Genetic Interaction Map Project]

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======= RPF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPF2
  * **<color #00a2e8>Official Name</color>**: ribosome production factor 2 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84154|84154]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7B2|Q9H7B2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618471|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Brix|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nucleolus|
|5S rRNA binding|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|ribosomal large subunit assembly|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|protein localization to nucleus|
|regulation of signal transduction by p53 class mediator|
|rRNA processing|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to organelle|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|RNA binding|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 238/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|7/28|
|bone|7/26|
|breast|8/33|
|central nervous system|30/56|
|cervix|3/4|
|colorectal|4/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|10/21|
|liver|4/20|
|lung|18/75|
|lymphocyte|7/16|
|ovary|7/26|
|pancreas|9/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 852
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPF2 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>