RPL10A [The Human Chemical-Genetic Interaction Map Project]

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======= RPL10A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL10A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L10a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4736|4736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62906|P62906]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL10A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL10A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit. {ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of LSU-rRNA|
|polysomal ribosome|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|response to ethanol|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|response to alcohol|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|response to antibiotic|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|response to toxic substance|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|response to drug|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.09|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.71|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.73|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.81|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.91|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.94|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.04|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.14|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.485|
|[[:human genes:k:krt78|KRT78]]|0.458|
|[[:human genes:o:orc6|ORC6]]|0.435|
|[[:human genes:s:supt5h|SUPT5H]]|0.429|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.424|
|[[:human genes:c:c14orf93|C14orf93]]|0.42|
|[[:human genes:t:ticrr|TICRR]]|0.416|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.414|
|[[:human genes:p:prim1|PRIM1]]|0.412|
|[[:human genes:t:tceb3c|TCEB3C]]|0.411|
|[[:human genes:p:plk4|PLK4]]|0.41|
|[[:human genes:n:napa|NAPA]]|0.41|
|[[:human genes:r:rpl7a|RPL7A]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.408|
|[[:human genes:t:tfip11|TFIP11]]|0.404|
|[[:human genes:c:cwc15|CWC15]]|0.401|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 644
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL10A Expression in NALM6 Cells: 8.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>