RPL14 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL14
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9045|9045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50914|P50914]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617414|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L14e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|cadherin binding|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.85|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.7|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.72|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.74|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.81|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.87|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.88|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.98|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.01|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.16|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.16|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.19|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.32|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.38|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.46|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.56|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:supt6h|SUPT6H]]|0.515|
|[[:human genes:o:orc1|ORC1]]|0.497|
|[[:human genes:w:wdr43|WDR43]]|0.497|
|[[:human genes:s:smg7|SMG7]]|0.486|
|[[:human genes:t:tfip11|TFIP11]]|0.486|
|[[:human genes:c:cdc6|CDC6]]|0.481|
|[[:human genes:d:dtl|DTL]]|0.48|
|[[:human genes:c:cdc73|CDC73]]|0.47|
|[[:human genes:n:nbpf10|NBPF10]]|0.469|
|[[:human genes:r:rpl17|RPL17]]|0.468|
|[[:human genes:e:exosc3|EXOSC3]]|0.466|
|[[:human genes:c:copb1|COPB1]]|0.465|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.465|
|[[:human genes:a:akirin2|AKIRIN2]]|0.464|
|[[:human genes:z:zfand5|ZFAND5]]|0.463|
|[[:human genes:p:pcf11|PCF11]]|0.459|
|[[:human genes:r:rps3a|RPS3A]]|0.457|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.453|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.452|
|[[:human genes:p:pola2|POLA2]]|0.448|
|[[:human genes:c:cep192|CEP192]]|0.448|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.447|
|[[:human genes:a:ankle2|ANKLE2]]|0.445|
|[[:human genes:c:ckap5|CKAP5]]|0.444|
|[[:human genes:c:c14orf93|C14orf93]]|0.443|
|[[:human genes:r:rps28|RPS28]]|0.442|
|[[:human genes:t:top1mt|TOP1MT]]|0.44|
|[[:human genes:p:polr2a|POLR2A]]|0.439|
|[[:human genes:c:copb2|COPB2]]|0.439|
|[[:human genes:v:vasn|VASN]]|0.438|
|[[:human genes:p:psmc1|PSMC1]]|0.437|
|[[:human genes:r:rpl6|RPL6]]|0.435|
|[[:human genes:c:copg1|COPG1]]|0.435|
|[[:human genes:n:nop16|NOP16]]|0.434|
|[[:human genes:r:rrp15|RRP15]]|0.434|
|[[:human genes:n:nupl1|NUPL1]]|0.434|
|[[:human genes:d:dido1|DIDO1]]|0.433|
|[[:human genes:n:nip7|NIP7]]|0.433|
|[[:human genes:p:psma7|PSMA7]]|0.433|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.432|
|[[:human genes:e:elmod3|ELMOD3]]|0.432|
|[[:human genes:r:rbm39|RBM39]]|0.431|
|[[:human genes:o:orc6|ORC6]]|0.431|
|[[:human genes:r:rps5|RPS5]]|0.43|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.429|
|[[:human genes:r:rpl37a|RPL37A]]|0.428|
|[[:human genes:s:sf3a3|SF3A3]]|0.428|
|[[:human genes:s:snrnp70|SNRNP70]]|0.427|
|[[:human genes:r:rpl34|RPL34]]|0.427|
|[[:human genes:m:myo1h|MYO1H]]|0.427|
|[[:human genes:c:cbwd3|CBWD3]]|0.426|
|[[:human genes:r:rpl26|RPL26]]|0.422|
|[[:human genes:p:psmc6|PSMC6]]|0.422|
|[[:human genes:n:nsf|NSF]]|0.421|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.421|
|[[:human genes:p:psmb1|PSMB1]]|0.421|
|[[:human genes:p:psmb4|PSMB4]]|0.42|
|[[:human genes:s:sf3a1|SF3A1]]|0.42|
|[[:human genes:p:psmd11|PSMD11]]|0.418|
|[[:human genes:r:rps2|RPS2]]|0.416|
|[[:human genes:c:cbwd5|CBWD5]]|0.416|
|[[:human genes:a:adrm1|ADRM1]]|0.415|
|[[:human genes:c:copz1|COPZ1]]|0.415|
|[[:human genes:r:rps14|RPS14]]|0.415|
|[[:human genes:c:ccna2|CCNA2]]|0.414|
|[[:human genes:r:rfpl3|RFPL3]]|0.413|
|[[:human genes:h:hap1|HAP1]]|0.413|
|[[:human genes:r:rps11|RPS11]]|0.413|
|[[:human genes:t:tram1|TRAM1]]|0.412|
|[[:human genes:r:rad51|RAD51]]|0.412|
|[[:human genes:d:ddx56|DDX56]]|0.412|
|[[:human genes:p:ppm1d|PPM1D]]|0.411|
|[[:human genes:g:gosr2|GOSR2]]|0.411|
|[[:human genes:r:rps12|RPS12]]|0.41|
|[[:human genes:n:nol10|NOL10]]|0.409|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.409|
|[[:human genes:s:sult2b1|SULT2B1]]|0.409|
|[[:human genes:c:c19orf53|C19orf53]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.408|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.408|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.408|
|[[:human genes:r:rpl35|RPL35]]|0.408|
|[[:human genes:n:nup205|NUP205]]|0.407|
|[[:human genes:m:med17|MED17]]|0.407|
|[[:human genes:c:cgb2|CGB2]]|0.406|
|[[:human genes:r:riok2|RIOK2]]|0.406|
|[[:human genes:g:gar1|GAR1]]|0.406|
|[[:human genes:i:ik|IK]]|0.405|
|[[:human genes:r:rpl30|RPL30]]|0.404|
|[[:human genes:t:twistnb|TWISTNB]]|0.404|
|[[:human genes:r:rps7|RPS7]]|0.404|
|[[:human genes:a:aqr|AQR]]|0.404|
|[[:human genes:l:lrr1|LRR1]]|0.403|
|[[:human genes:t:terf1|TERF1]]|0.403|
|[[:human genes:c:cln6|CLN6]]|0.403|
|[[:human genes:e:exosc5|EXOSC5]]|0.402|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.402|
|[[:human genes:c:cbwd6|CBWD6]]|0.402|
|[[:human genes:z:znf106|ZNF106]]|0.401|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
|[[:human genes:i:ints6|INTS6]]|0.4|
|[[:human genes:s:slc4a1|SLC4A1]]|0.4|
|[[:human genes:t:taf1|TAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL14 Expression in NALM6 Cells: 9.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>