RPL22 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL22
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L22
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6146|6146]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35268|P35268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L22e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of translation at presynapse|
|regulation of translation at presynapse, modulating synaptic transmission|
|regulation of translation at synapse|
|regulation of translation at synapse, modulating synaptic transmission|
|presynaptic modulation of chemical synaptic transmission|
|translation regulator activity|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|cytosolic large ribosomal subunit|
|presynapse|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|T cell differentiation|
|protein localization to endoplasmic reticulum|
|translational initiation|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|heparin binding|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|T cell activation|
|lymphocyte differentiation|
|RNA catabolic process|
|establishment of protein localization to membrane|
|leukocyte differentiation|
|glutamatergic synapse|
|regulation of translation|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|lymphocyte activation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|modulation of chemical synaptic transmission|
|aromatic compound catabolic process|
|regulation of trans-synaptic signaling|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|leukocyte activation|
|intracellular protein transport|
|macromolecule catabolic process|
|cell activation|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.04|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.93|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.74|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.79|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.87|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.87|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.04|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2.06|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.42|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|4.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3064
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL22 Expression in NALM6 Cells: 8.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>