RPL27 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL27
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6155|6155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61353|P61353]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607526|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L27e family of ribosomal proteins and a component of the 60S subunit. A splice site mutation in this gene has been identified in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (PubMed:25424902). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25424902, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L27e|
|KOW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of rough endoplasmic reticulum membrane|
|ribosome|
|cytosolic large ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|ribonucleoprotein complex|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.75|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.73|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.73|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.77|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.03|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.05|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.16|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.458|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.441|
|[[:human genes:c:c19orf53|C19orf53]]|0.437|
|[[:human genes:r:rpl6|RPL6]]|0.419|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.406|
|[[:human genes:r:rpl18|RPL18]]|0.405|
|[[:human genes:i:ints1|INTS1]]|0.403|
|[[:human genes:c:chd4|CHD4]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 216
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL27 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>