RPL37A [The Human Chemical-Genetic Interaction Map Project]

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======= RPL37A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL37A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L37a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6168|6168]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61513|P61513]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL37A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL37A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613314|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L37ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytosolic large ribosomal subunit|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.89|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.71|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.77|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.79|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.85|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.86|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.87|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.88|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.97|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.06|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.14|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.3|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.6|
|[[:human genes:c:cope|COPE]]|0.492|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.485|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.46|
|[[:human genes:g:gar1|GAR1]]|0.458|
|[[:human genes:t:tfip11|TFIP11]]|0.456|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.441|
|[[:human genes:o:orc1|ORC1]]|0.435|
|[[:human genes:t:tceb3c|TCEB3C]]|0.433|
|[[:human genes:r:rpl14|RPL14]]|0.428|
|[[:human genes:t:tcf25|TCF25]]|0.427|
|[[:human genes:s:shpk|SHPK]]|0.422|
|[[:human genes:s:spata13|SPATA13]]|0.422|
|[[:human genes:p:parp3|PARP3]]|0.418|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.417|
|[[:human genes:p:psmd7|PSMD7]]|0.417|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.416|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.41|
|[[:human genes:v:vps28|VPS28]]|0.41|
|[[:human genes:c:chaf1a|CHAF1A]]|0.408|
|[[:human genes:e:exd1|EXD1]]|0.407|
|[[:human genes:c:cmya5|CMYA5]]|0.403|
|[[:human genes:a:aqr|AQR]]|0.402|
|[[:human genes:p:polr2a|POLR2A]]|0.402|
|[[:human genes:z:znf335|ZNF335]]|0.401|
|[[:human genes:h:hivep3|HIVEP3]]|0.401|
|[[:human genes:c:cactin|CACTIN]]|0.401|
|[[:human genes:n:nol12|NOL12]]|0.401|
|[[:human genes:u:utp20|UTP20]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 605/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|21/28|
|bone|22/26|
|breast|26/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|15/20|
|lung|60/75|
|lymphocyte|12/16|
|ovary|24/26|
|pancreas|19/24|
|peripheral nervous system|11/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL37A Expression in NALM6 Cells: 9.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>