RPL39 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL39
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6170|6170]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62891|P62891]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300899|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L39|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|innate immune response in mucosa|
|mucosal immune response|
|organ or tissue specific immune response|
|polysomal ribosome|
|antibacterial humoral response|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|cytosolic large ribosomal subunit|
|cytoplasmic translation|
|defense response to Gram-positive bacterium|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|antimicrobial humoral response|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|defense response to bacterium|
|humoral immune response|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|response to bacterium|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|innate immune response|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|defense response to other organism|
|intracellular protein transport|
|macromolecule catabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 66/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|3/28|
|blood|1/26|
|bone|5/26|
|breast|4/30|
|central nervous system|2/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/11|
|fibroblast|0/1|
|gastric|2/14|
|kidney|2/18|
|liver|0/19|
|lung|8/72|
|lymphocyte|1/16|
|ovary|1/25|
|pancreas|0/22|
|peripheral nervous system|3/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|7/20|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 282
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL39 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>