RPL6 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL6
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6128|6128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q02878|Q02878]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the large ribosomal subunit. {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:25957688, ECO:0000305|PubMed:12962325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L6e|
|Ribosomal L6e N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal large subunit assembly|
|polysomal ribosome|
|rough endoplasmic reticulum|
|ribosome assembly|
|cytosolic large ribosomal subunit|
|cytoplasmic ribonucleoprotein granule|
|ribosomal large subunit biogenesis|
|cytoplasmic translation|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|postsynaptic density|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|cadherin binding|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.79|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nol10|NOL10]]|0.557|
|[[:human genes:p:psmb4|PSMB4]]|0.557|
|[[:human genes:r:rpl35|RPL35]]|0.537|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.525|
|[[:human genes:t:tceb3c|TCEB3C]]|0.522|
|[[:human genes:n:nol12|NOL12]]|0.521|
|[[:human genes:c:chd4|CHD4]]|0.519|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.516|
|[[:human genes:c:cln6|CLN6]]|0.513|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.508|
|[[:human genes:r:rps12|RPS12]]|0.508|
|[[:human genes:g:golga8o|GOLGA8O]]|0.506|
|[[:human genes:p:polr2j3|POLR2J3]]|0.504|
|[[:human genes:r:rps7|RPS7]]|0.499|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.499|
|[[:human genes:n:npipb8|NPIPB8]]|0.499|
|[[:human genes:t:timeless|TIMELESS]]|0.497|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.497|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.494|
|[[:human genes:m:mki67ip|MKI67IP]]|0.491|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.489|
|[[:human genes:r:rpl17|RPL17]]|0.488|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.487|
|[[:human genes:n:narfl|NARFL]]|0.486|
|[[:human genes:p:psma6|PSMA6]]|0.483|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.479|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.479|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.478|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.478|
|[[:human genes:p:pola2|POLA2]]|0.478|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.476|
|[[:human genes:r:rps2|RPS2]]|0.476|
|[[:human genes:r:rbbp5|RBBP5]]|0.476|
|[[:human genes:t:ticrr|TICRR]]|0.473|
|[[:human genes:h:hap1|HAP1]]|0.473|
|[[:human genes:d:dtl|DTL]]|0.473|
|[[:human genes:k:krt78|KRT78]]|0.473|
|[[:human genes:o:orc1|ORC1]]|0.47|
|[[:human genes:i:igfn1|IGFN1]]|0.469|
|[[:human genes:r:rpl30|RPL30]]|0.469|
|[[:human genes:p:ppm1d|PPM1D]]|0.468|
|[[:human genes:r:rad51|RAD51]]|0.463|
|[[:human genes:r:rpl13|RPL13]]|0.463|
|[[:human genes:p:psma7|PSMA7]]|0.461|
|[[:human genes:s:slc6a17|SLC6A17]]|0.459|
|[[:human genes:c:cdc73|CDC73]]|0.457|
|[[:human genes:c:cactin|CACTIN]]|0.456|
|[[:human genes:b:brd2|BRD2]]|0.453|
|[[:human genes:t:tspy2|TSPY2]]|0.453|
|[[:human genes:s:ssh2|SSH2]]|0.45|
|[[:human genes:d:ddx47|DDX47]]|0.449|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.448|
|[[:human genes:r:rpl9|RPL9]]|0.448|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.448|
|[[:human genes:a:aqr|AQR]]|0.447|
|[[:human genes:t:tspy1|TSPY1]]|0.446|
|[[:human genes:c:c14orf93|C14orf93]]|0.446|
|[[:human genes:c:ctage4|CTAGE4]]|0.444|
|[[:human genes:p:psmb3|PSMB3]]|0.444|
|[[:human genes:d:dhx38|DHX38]]|0.443|
|[[:human genes:a:aatf|AATF]]|0.443|
|[[:human genes:f:fam160a1|FAM160A1]]|0.443|
|[[:human genes:c:cdca3|CDCA3]]|0.443|
|[[:human genes:n:nupl1|NUPL1]]|0.443|
|[[:human genes:c:ccdc116|CCDC116]]|0.443|
|[[:human genes:m:mfsd12|MFSD12]]|0.44|
|[[:human genes:e:exosc9|EXOSC9]]|0.44|
|[[:human genes:r:rpl34|RPL34]]|0.439|
|[[:human genes:r:rpl31|RPL31]]|0.438|
|[[:human genes:k:kctd17|KCTD17]]|0.438|
|[[:human genes:p:ppan|PPAN]]|0.438|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.438|
|[[:human genes:d:ddtl|DDTL]]|0.437|
|[[:human genes:t:tuba8|TUBA8]]|0.437|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.437|
|[[:human genes:b:brix1|BRIX1]]|0.437|
|[[:human genes:u:utp3|UTP3]]|0.437|
|[[:human genes:w:wdr87|WDR87]]|0.436|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.436|
|[[:human genes:z:znf574|ZNF574]]|0.436|
|[[:human genes:r:rpl14|RPL14]]|0.435|
|[[:human genes:c:cdh24|CDH24]]|0.435|
|[[:human genes:v:vasn|VASN]]|0.435|
|[[:human genes:p:pola1|POLA1]]|0.434|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.434|
|[[:human genes:c:cbwd5|CBWD5]]|0.434|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.432|
|[[:human genes:a:akt1s1|AKT1S1]]|0.432|
|[[:human genes:r:rps3a|RPS3A]]|0.431|
|[[:human genes:s:s1pr4|S1PR4]]|0.431|
|[[:human genes:c:cep192|CEP192]]|0.431|
|[[:human genes:p:psmc1|PSMC1]]|0.43|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.43|
|[[:human genes:r:rrp1|RRP1]]|0.429|
|[[:human genes:p:polr1a|POLR1A]]|0.429|
|[[:human genes:z:zfand5|ZFAND5]]|0.429|
|[[:human genes:r:rrp15|RRP15]]|0.429|
|[[:human genes:n:nsf|NSF]]|0.428|
|[[:human genes:r:rpl15|RPL15]]|0.427|
|[[:human genes:v:vps28|VPS28]]|0.426|
|[[:human genes:c:copa|COPA]]|0.426|
|[[:human genes:a:art5|ART5]]|0.426|
|[[:human genes:p:pcf11|PCF11]]|0.425|
|[[:human genes:c:cbwd3|CBWD3]]|0.425|
|[[:human genes:d:dido1|DIDO1]]|0.425|
|[[:human genes:e:exosc8|EXOSC8]]|0.425|
|[[:human genes:r:rps5|RPS5]]|0.424|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.424|
|[[:human genes:e:exosc5|EXOSC5]]|0.424|
|[[:human genes:p:paf1|PAF1]]|0.424|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.423|
|[[:human genes:h:hinfp|HINFP]]|0.423|
|[[:human genes:p:psmb1|PSMB1]]|0.423|
|[[:human genes:o:orc6|ORC6]]|0.422|
|[[:human genes:a:akirin2|AKIRIN2]]|0.422|
|[[:human genes:c:cdc6|CDC6]]|0.421|
|[[:human genes:c:copb1|COPB1]]|0.421|
|[[:human genes:h:heatr1|HEATR1]]|0.421|
|[[:human genes:p:psmd2|PSMD2]]|0.421|
|[[:human genes:r:rps19|RPS19]]|0.42|
|[[:human genes:r:rrp7a|RRP7A]]|0.42|
|[[:human genes:r:rpl27|RPL27]]|0.419|
|[[:human genes:l:lad1|LAD1]]|0.419|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.419|
|[[:human genes:s:supt6h|SUPT6H]]|0.419|
|[[:human genes:a:agap5|AGAP5]]|0.419|
|[[:human genes:c:ctr9|CTR9]]|0.419|
|[[:human genes:z:znf583|ZNF583]]|0.418|
|[[:human genes:b:bysl|BYSL]]|0.416|
|[[:human genes:p:psmc6|PSMC6]]|0.416|
|[[:human genes:t:tspy8|TSPY8]]|0.416|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.414|
|[[:human genes:s:sart1|SART1]]|0.414|
|[[:human genes:n:ngdn|NGDN]]|0.413|
|[[:human genes:a:aamp|AAMP]]|0.413|
|[[:human genes:l:lrr1|LRR1]]|0.412|
|[[:human genes:s:slc38a7|SLC38A7]]|0.412|
|[[:human genes:t:ttc31|TTC31]]|0.412|
|[[:human genes:n:ncl|NCL]]|0.411|
|[[:human genes:t:twistnb|TWISTNB]]|0.41|
|[[:human genes:m:myo18a|MYO18A]]|0.41|
|[[:human genes:g:gga3|GGA3]]|0.41|
|[[:human genes:m:mcoln1|MCOLN1]]|0.41|
|[[:human genes:s:sf3a3|SF3A3]]|0.41|
|[[:human genes:i:ik|IK]]|0.409|
|[[:human genes:p:pwp2|PWP2]]|0.408|
|[[:human genes:c:col2a1|COL2A1]]|0.408|
|[[:human genes:s:syt9|SYT9]]|0.408|
|[[:human genes:f:fam25b|FAM25B]]|0.407|
|[[:human genes:r:rps6|RPS6]]|0.407|
|[[:human genes:n:nup98|NUP98]]|0.407|
|[[:human genes:s:supt5h|SUPT5H]]|0.407|
|[[:human genes:s:snrnp70|SNRNP70]]|0.406|
|[[:human genes:t:tyms|TYMS]]|0.406|
|[[:human genes:g:gosr2|GOSR2]]|0.406|
|[[:human genes:p:pan3|PAN3]]|0.405|
|[[:human genes:r:rps20|RPS20]]|0.405|
|[[:human genes:n:ncapg|NCAPG]]|0.405|
|[[:human genes:e:exosc4|EXOSC4]]|0.404|
|[[:human genes:d:dhfr|DHFR]]|0.404|
|[[:human genes:e:exosc6|EXOSC6]]|0.404|
|[[:human genes:z:znf830|ZNF830]]|0.404|
|[[:human genes:s:slc4a1|SLC4A1]]|0.404|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.404|
|[[:human genes:m:mms22l|MMS22L]]|0.403|
|[[:human genes:z:znf106|ZNF106]]|0.403|
|[[:human genes:r:rps9|RPS9]]|0.402|
|[[:human genes:f:fbxw9|FBXW9]]|0.402|
|[[:human genes:c:cacna1a|CACNA1A]]|0.402|
|[[:human genes:m:mcm7|MCM7]]|0.402|
|[[:human genes:a:ankle1|ANKLE1]]|0.401|
|[[:human genes:n:nbpf16|NBPF16]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 427/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|14/28|
|bone|14/26|
|breast|18/33|
|central nervous system|32/56|
|cervix|1/4|
|colorectal|9/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|17/21|
|liver|11/20|
|lung|49/75|
|lymphocyte|8/16|
|ovary|16/26|
|pancreas|11/24|
|peripheral nervous system|6/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|11/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL6 Expression in NALM6 Cells: 9.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>