RPL7A [The Human Chemical-Genetic Interaction Map Project]

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======= RPL7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL7A
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L7a
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6130|6130]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62424|P62424]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L7Ae|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of LSU-rRNA|
|polysomal ribosome|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein targeting to membrane|
|structural constituent of ribosome|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|establishment of protein localization to membrane|
|ribosome biogenesis|
|cadherin binding|
|protein targeting|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|protein localization to membrane|
|organic cyclic compound catabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.81|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.72|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.72|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.76|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.76|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.84|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.91|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.97|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.97|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.97|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.11|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.19|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.23|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.28|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.514|
|[[:human genes:p:pola2|POLA2]]|0.485|
|[[:human genes:n:nol12|NOL12]]|0.439|
|[[:human genes:v:vasn|VASN]]|0.434|
|[[:human genes:n:nup133|NUP133]]|0.425|
|[[:human genes:r:rrm2|RRM2]]|0.425|
|[[:human genes:a:apobec3a|APOBEC3A]]|0.421|
|[[:human genes:o:ogfr|OGFR]]|0.414|
|[[:human genes:x:xylt2|XYLT2]]|0.413|
|[[:human genes:r:rpl10a|RPL10A]]|0.409|
|[[:human genes:r:rps19|RPS19]]|0.407|
|[[:human genes:r:rps15|RPS15]]|0.405|
|[[:human genes:s:slamf1|SLAMF1]]|0.404|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:r:rpl32|RPL32]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 47
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL7A Expression in NALM6 Cells: 9.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>