RPL7L1 [The Human Chemical-Genetic Interaction Map Project]

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======= RPL7L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPL7L1
  * **<color #00a2e8>Official Name</color>**: ribosomal protein L7 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285855|285855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6DKI1|Q6DKI1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPL7L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPL7L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617417|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L30|
|Ribosomal L30 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|blastocyst formation|
|cytosolic large ribosomal subunit|
|ribosomal large subunit biogenesis|
|blastocyst development|
|structural constituent of ribosome|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|in utero embryonic development|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|nucleolus|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.78|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.81|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.88|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.89|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.89|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.92|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.97|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.05|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.05|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.17|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dock6|DOCK6]]|0.491|
|[[:human genes:r:rrp15|RRP15]]|0.47|
|[[:human genes:r:rpl14|RPL14]]|0.465|
|[[:human genes:s:snrnp70|SNRNP70]]|0.459|
|[[:human genes:o:orc6|ORC6]]|0.455|
|[[:human genes:k:kctd17|KCTD17]]|0.455|
|[[:human genes:v:vasn|VASN]]|0.445|
|[[:human genes:r:rad51|RAD51]]|0.442|
|[[:human genes:c:cdc73|CDC73]]|0.441|
|[[:human genes:i:ik|IK]]|0.439|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.439|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.435|
|[[:human genes:i:igfn1|IGFN1]]|0.432|
|[[:human genes:c:ckap5|CKAP5]]|0.427|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.426|
|[[:human genes:k:krt78|KRT78]]|0.424|
|[[:human genes:s:slc4a1|SLC4A1]]|0.424|
|[[:human genes:r:rpl6|RPL6]]|0.423|
|[[:human genes:p:pan3|PAN3]]|0.423|
|[[:human genes:p:polr2a|POLR2A]]|0.421|
|[[:human genes:s:syt9|SYT9]]|0.419|
|[[:human genes:d:dtl|DTL]]|0.417|
|[[:human genes:t:tfrc|TFRC]]|0.416|
|[[:human genes:r:rpl35|RPL35]]|0.416|
|[[:human genes:g:golga6a|GOLGA6A]]|0.416|
|[[:human genes:c:cdc6|CDC6]]|0.415|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.415|
|[[:human genes:p:psmc1|PSMC1]]|0.414|
|[[:human genes:n:nupl1|NUPL1]]|0.412|
|[[:human genes:p:pole|POLE]]|0.412|
|[[:human genes:z:zfand5|ZFAND5]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.411|
|[[:human genes:c:chaf1a|CHAF1A]]|0.409|
|[[:human genes:c:cope|COPE]]|0.409|
|[[:human genes:n:narfl|NARFL]]|0.408|
|[[:human genes:s:sf3a1|SF3A1]]|0.408|
|[[:human genes:s:snrnp200|SNRNP200]]|0.407|
|[[:human genes:p:psma6|PSMA6]]|0.405|
|[[:human genes:p:pola2|POLA2]]|0.405|
|[[:human genes:p:prpf3|PRPF3]]|0.404|
|[[:human genes:s:supt6h|SUPT6H]]|0.402|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.402|
|[[:human genes:w:wdr43|WDR43]]|0.402|
|[[:human genes:r:rrn3|RRN3]]|0.402|
|[[:human genes:p:plxnb3|PLXNB3]]|0.401|
|[[:human genes:r:rpp40|RPP40]]|0.4|
|[[:human genes:c:cln6|CLN6]]|0.4|
|[[:human genes:p:paf1|PAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 75/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|2/28|
|bone|2/26|
|breast|5/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|2/21|
|liver|0/20|
|lung|6/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPL7L1 Expression in NALM6 Cells: 8.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>