RPS15 [The Human Chemical-Genetic Interaction Map Project]

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======= RPS15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RPS15
  * **<color #00a2e8>Official Name</color>**: ribosomal protein S15
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6209|6209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62841|P62841]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RPS15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RPS15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal S19|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal small subunit export from nucleus|
|ribosomal subunit export from nucleus|
|ribosome localization|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|ribosomal small subunit assembly|
|cytosolic small ribosomal subunit|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|viral transcription|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|osteoblast differentiation|
|RNA export from nucleus|
|viral gene expression|
|protein localization to endoplasmic reticulum|
|translational initiation|
|protein export from nucleus|
|nuclear export|
|protein targeting to membrane|
|structural constituent of ribosome|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|RNA localization|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|protein-containing complex localization|
|ossification|
|establishment of protein localization to membrane|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|protein targeting|
|establishment of organelle localization|
|nucleobase-containing compound catabolic process|
|translation|
|ncRNA processing|
|peptide biosynthetic process|
|focal adhesion|
|establishment of protein localization to organelle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|protein localization to membrane|
|amide biosynthetic process|
|peptide metabolic process|
|organelle localization|
|mRNA metabolic process|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.81|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.84|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.519|
|[[:human genes:r:rpl7a|RPL7A]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 529/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|17/28|
|bone|14/26|
|breast|22/33|
|central nervous system|49/56|
|cervix|2/4|
|colorectal|13/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|14/21|
|liver|15/20|
|lung|47/75|
|lymphocyte|10/16|
|ovary|21/26|
|pancreas|12/24|
|peripheral nervous system|9/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 75
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RPS15 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>